Zoekresultaten

Factors driving the spatial layout of distribution channels

Research statementOur study analyses the factors that drive decision-making on distribution structures, including the layout of distribution channels and the locations of distribution centres. Distribution is a primary firm activity, which strongly influences logistics costs and logistics performance. Distribution is a challenging activity as customer demand is often volatile and unpredictable. Consumers continuously expect higher service related to distribution, e.g., same day delivery and more flexibility in delivery locations. Therefore, it is of strategic importance to shippers and Logistics Service Providers (LSPs) to decide which distribution channel layout to use and, accordingly, plan distribution centre location(s). Distribution structure selection concerns the number and locations of distribution centres, as part of the larger corporate planning process. The main questions we strive to answer in this paper are: (1) what are the main criteria that determine the spatial layout of distribution structures? and (2) how important are these criteria, relative to each other?Methodology The literature on distribution channel design mostly revolves around optimization methods; we are not aware of literature that takes a descriptive approach. We therefore develop a descriptive conceptual model that includes these factors, developed from the contextual literature around this decision. The second part of the study concerns the measurement of the relative importance of these factors. We implemented an elaborate survey and used the Best-Worst Method (BWM) to identify these weights. The survey considers different experts (e.g., logistics managers versus logistics professors) and population segments (e.g., in-house versus outsourced distribution).Data and resultsCurrently we are completing the survey dedicated to evaluating the above factors. We have received sufficient response to estimate a first model. These first estimations already provide useful results. Final estimations will be completed and reported in June 2017. At the I-NUF conference we will be able to present the results and analysis of all factors when comparing respondents and parameters.Preliminary conclusionsBased on literature review, eight main factors – divided into 33 sub factors – are included in our research: 1) Demand factors, 2) Service level factors, 3) Product Characteristics factors, 4) Logistics costs factors, 5) Proximity-related location factors, 6) Accessibility-related location factors, 7) Resources-related location factors and 8) Institutional factors. A number of hypotheses were built from the literature analysis relating, for example, to the relative importance of service- and cost- related factors within different industries. We will revisit these hypotheses and provide the quantitative results of the importance of the individual factors in our paper and at the conference.

A closed-loop ventilation mode that targets the lowest work and force of breathing reduces the transpulmonary driving pressure in patients with moderate-to-severe ARDS

IntroductionThe driving pressure (ΔP) has an independent association with outcome in patients with acute respiratory distress syndrome (ARDS). INTELLiVENT-Adaptive Support Ventilation (ASV) is a closed-loop mode of ventilation that targets the lowest work and force of breathing.AimTo compare transpulmonary and respiratory system ΔP between closed-loop ventilation and conventional pressure controlled ventilation in patients with moderate-to-severe ARDS.MethodsSingle-center randomized cross-over clinical trial in patients in the early phase of ARDS. Patients were randomly assigned to start with a 4-h period of closed-loop ventilation or conventional ventilation, after which the alternate ventilation mode was selected. The primary outcome was the transpulmonary ΔP; secondary outcomes included respiratory system ΔP, and other key parameters of ventilation.ResultsThirteen patients were included, and all had fully analyzable data sets. Compared to conventional ventilation, with closed-loop ventilation the median transpulmonary ΔP with was lower (7.0 [5.0–10.0] vs. 10.0 [8.0–11.0] cmH2O, mean difference − 2.5 [95% CI − 2.6 to − 2.1] cmH2O; P = 0.0001). Inspiratory transpulmonary pressure and the respiratory rate were also lower. Tidal volume, however, was higher with closed-loop ventilation, but stayed below generally accepted safety cutoffs in the majority of patients.ConclusionsIn this small physiological study, when compared to conventional pressure controlled ventilation INTELLiVENT-ASV reduced the transpulmonary ΔP in patients in the early phase of moderate-to-severe ARDS. This closed-loop ventilation mode also led to a lower inspiratory transpulmonary pressure and a lower respiratory rate, thereby reducing the intensity of ventilation.Trial registration Clinicaltrials.gov, NCT03211494, July 7, 2017. https://clinicaltrials.gov/ct2/show/NCT03211494?term=airdrop&draw=2&rank=1.

Adverse effects of anxiety on attentional control differ as a function of experience

Measuring emotions driving an autonomous vehicle : A visual of someone driving an autonomous car in a virtual reality environment

Veranderende automotive wereld vraagt om verandering onderwijs

Met dit document wil ik de lezer een nieuwe invalshoek tonen op mobiliteit (Driving Guidance) en een andere benadering van automotive hbo onderwijs. De wereld om ons heen verandert en deze nieuwe wereld zal een ander type automotive ingenieur eisen. Dit is een korte weergave van een lezing voor de MBO-raad onderafdeling docenten automotive (Onderstructuur Btg MCT). De presentatie is gehouden op Miniconferentie Onderstructuur Btg MCT op 23 april 2010 bij Innovam te Nieuwegein. Kort worden trends op wereldniveau geschetst waarna wordt afgedaald naar het niveau van mijn werkplek. Het pad verloopt via niveau van Nederland, Regio Eindhoven, Helmond en tenslotte eindigt het pad bij Lectoraat Automotive Control. Als voorbeeld wordt het project Cooperative Driving getoond. Parallel aan de schets van werkzaamheden wordt besproken wat de veranderingen zijn in automotive onderwijs. Traditioneel komt automotive vanuit de invalshoek werktuigbouwkunde. De nieuwe opleidingen automotive HBO en WO zijn meer gericht op de drie componenten werktuigbouwkunde, elektrotechniek en ICT.

Driving Performance in Patients With Idiopathic Cervical Dystonia; A Driving Simulator Pilot Study

Objective: To explore driving performance and driving safety in patients with cervical dystonia (CD) on a simulated lane tracking, intersections and highway ride and to compare it to healthy controls. Design: This study was performed as an explorative between groups comparison. Participants: Ten CD patients with idiopathic CD, 30 years or older, stable on botulinum toxin treatment for over a year, holding a valid driver's license and being an active driver were compared with 10 healthy controls, matched for age and gender. Main outcome measures: Driving performance and safety, measured by various outcomes from the simulator, such as the standard deviation of the lateral position on the road, rule violations, percentage of line crossings, gap distance, and number of collisions. Fatigue and driving effort were measured with the Borg CR-10 scale and self-perceived fitness to drive was assessed with Fitness to Drive Screening. Results: Except for a higher percentage of line crossings on the right side of the road by controls (median percentage 2.30, range 0.00-37.00 vs. 0.00, range 0.00-9.20, p = 0.043), no differences were found in driving performance and driving safety during the simulator rides. Fatigue levels were significantly higher in CD patients just before (p = 0.005) and after (p = 0.033) the lane tracking ride (patients median fatigue levels before 1.5 (range 0.00-6.00) and after 1.5 (range 0.00-7.00) vs. controls median fatigue levels before and after 0.00 (no range). No significant differences were found on self-perceived fitness to drive. Conclusion: In patients with CD there were no indications that driving performance or driving safety were significant different from healthy controls in a simulator. Patients reported higher levels of fatigue both before and after driving compared to controls in accordance with the non-motor symptoms known in CD.