Zoekresultaten

Post-precariteit

Een exploratie van principes voor beleid, zelforganisatie en solidariteit voor cultuur aan gene zijde van de Covid-crisis

Optimal Dosing and Timing of High-Dose Corticosteroid Therapy in Hospitalized Patients With COVID-19

Background:In hospitalized patients with COVID-19, the dosing and timing of corticosteroids vary widely. Low-dose dexamethasone therapy reduces mortality in patients requiring respiratory support, but it remains unclear how to treat patients when this therapy fails. In critically ill patients, high-dose corticosteroids are often administered as salvage late in the disease course, whereas earlier administration may be more beneficial in preventing disease progression. Previous research has revealed that increased levels of various biomarkers are associated with mortality, and whole blood transcriptome sequencing has the ability to identify host factors predisposing to critical illness in patients with COVID-19.Objective:Our goal is to determine the most optimal dosing and timing of corticosteroid therapy and to provide a basis for personalized corticosteroid treatment regimens to reduce morbidity and mortality in hospitalized patients with COVID-19.Methods:This is a retrospective, observational, multicenter study that includes adult patients who were hospitalized due to COVID-19 in the Netherlands. We will use the differences in therapeutic strategies between hospitals (per protocol high-dose corticosteroids or not) over time to determine whether high-dose corticosteroids have an effect on the following outcome measures: mechanical ventilation or high-flow nasal cannula therapy, in-hospital mortality, and 28-day survival. We will also explore biomarker profiles in serum and bronchoalveolar lavage fluid and use whole blood transcriptome analysis to determine factors that influence the relationship between high-dose corticosteroids and outcome. Existing databases that contain routinely collected electronic data during ward and intensive care admissions, as well as existing biobanks, will be used. We will apply longitudinal modeling appropriate for each data structure to answer the research questions at hand.Results:As of April 2023, data have been collected for a total of 1500 patients, with data collection anticipated to be completed by December 2023. We expect the first results to be available in early 2024.Conclusions:This study protocol presents a strategy to investigate the effect of high-dose corticosteroids throughout the entire clinical course of hospitalized patients with COVID-19, from hospital admission to the ward or intensive care unit until hospital discharge. Moreover, our exploration of biomarker and gene expression profiles for targeted corticosteroid therapy represents a first step towards personalized COVID-19 corticosteroid treatment.Trial Registration:ClinicalTrials.gov NCT05403359; https://clinicaltrials.gov/ct2/show/NCT05403359International Registered Report Identifier (IRRID):DERR1-10.2196/48183

Zicht op Evenwicht : Meten van bezoekersstromen en leefbaarheid.

Facilitating campus interactions – critical success factors according to university facility directors

Purpose: The purpose of this paper is to investigate which critical success factors (CSFs) influence interaction on campuses as identified by the facility directors (FDs) of Dutch university campuses and to discuss how these compare with the literature. Design/methodology/approach: All 13 Dutch university campus FDs were interviewed (office and walking interview), focussing on CSFs relating to spaces and services that facilitate interaction. Open coding and thematic analysis resulted in empirically driven categories indicated by the respondents. Similarities and differences between the CSFs as previously identified in the literature are discussed. Findings: The following categories emerged: constraints, motivators, designing spaces, designing services, building community and creating coherence. The campus is seen as a system containing subsystems and is itself part of a wider system (environment), forming a layered structure. Constraints and motivators are part of the environment but cannot be separated from the other four categories, as they influence their applicability. Research limitations/implications: This study was limited to interviews with FDs and related staff. The richness of the findings shows that this was a relevant and efficient data collection strategy for the purpose of this study. Practical implications: By viewing the campus as an open system, this study puts the practical applicability of CSFs into perspective yet provides a clear overview of CSFs related to campus interaction that may be included in future campus design policies. Social implications: This (more) complete overview of CSFs identified in both literature and practice will help FDs, policymakers and campus designers to apply these CSFs in their campus designs. This improved campus design would increase the number of knowledge sharing interactions, contributing to innovation and valorisation. This could create a significant impact in all research fields, such as health, technology or well-being, benefitting society as a whole. Originality/value: This study provides a comprehensive overview and comparison of CSFs from both literature and practice, allowing more effective application of CSFs in campus design policies. A framework for future studies on CSFs for interaction on campuses is provided.

Zorghotel Pitstop

Dit is het verslag van een onderzoek naar het reilen en zeilen van het Zorghotel Pitstop. Doel van het onderzoek is om in kaart te brengen hoe in deze voorziening vorm gegeven wordt aan cliëntsturing/zelfbeheer en herstel, welke knelpunten en spanningen daarmee gepaard gaan, welke leer- en ontwikkelprocessen zich daarbij voordoen en welke faciliteiten daarbij nodig zijn.

Hoe Amsterdamse campussen zich positioneren als bedrijfslocaties

Amsterdam heeft verschillende campussen en innovatiegebieden. Van oudsher zijn dit vooral plekken voor kennisinstellingen, maar de laatste jaren zijn ze meer divers geworden. Veel campussen richten zich nu ook expliciet op bedrijven, vooral kennisintensieve startups en scale-ups. Ze profileren zich als aantrekkelijke vestigingsplaatsen waar bedrijven samenwerkingen kunnen aangaan met onderzoek en onderwijs, en/of gebruik kunnen maken van specialistische faciliteiten die op de campus aanwezig zijn. Dit rapport bevat een eerste verkenning van de huidige situatie met betrekking tot het vestigen van bedrijven op de grotere campussen/innovatiedistricten in Amsterdam. Wat gebeurt er momenteel op de campussen om bedrijven aan te trekken, te huisvesten, en te binden aan de campus? Welke locatieprofielen ontwikkelen zich?