Greenport West-Holland en de EconomicBoard Zuid Holland werken samen aan de ontwikkeling en uitvoering van een human capitalagenda (HCA) voor de provincie en de Greenport. Hiervoor wordt in juni –juli 2019 een Human CapitalAkkoord gesloten met meerdere sectoren waaronder de Greenport. Onderdeel van het akkoord is een gezamenlijke investering in een eerste pilot (2019 –2022) met een focus op van Werk naar Werk. Greenport West-Holland heeft aan de hand van de bestaande HCA van de topsector tuinbouw & uitgangsmaterialen, Techniek pact, Groen pact, ambities van Glastuinbouw Nederland, AVAG, handel en de inbreng vanuit de mooie voorbeelden in de regio (de pareltjes), individuele ondernemers en gemeenten een samenhangend pakket van interventies uitgewerkt. Deze interventies sluiten voor een groot deel aan op de EBZ pilot doelstellingen (VET), maar niet allemaal. De interventies maken zoveel mogelijk gebruik van bestaande oplossingen (pareltjes) die versterkt en verbonden worden.
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For people with early-dementia (PwD), it can be challenging to remember to eat and drink regularly and maintain a healthy independent living. Existing intelligent home technologies primarily focus on activity recognition but lack adaptive support. This research addresses this gap by developing an AI system inspired by the Just-in-Time Adaptive Intervention (JITAI) concept. It adapts to individual behaviors and provides personalized interventions within the home environment, reminding and encouraging PwD to manage their eating and drinking routines. Considering the cognitive impairment of PwD, we design a human-centered AI system based on healthcare theories and caregivers’ insights. It employs reinforcement learning (RL) techniques to deliver personalized interventions. To avoid overwhelming interaction with PwD, we develop an RL-based simulation protocol. This allows us to evaluate different RL algorithms in various simulation scenarios, not only finding the most effective and efficient approach but also validating the robustness of our system before implementation in real-world human experiments. The simulation experimental results demonstrate the promising potential of the adaptive RL for building a human-centered AI system with perceived expressions of empathy to improve dementia care. To further evaluate the system, we plan to conduct real-world user studies.
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The percentage of sports and leisure shoes sold worldwide is gradually increasing. However, consumers have little or no objective information on the mechanical properties of the shoes. A justified selection protocol of sports and leisure shoes based on static and dynamic shoe properties considering the intended use is essential. Today, commonly accepted dynamic test protocols for (sports) shoes do not exist. The development of an artificial parametric foot as part of an innovative robot gait simulator is a tool to objectify shoe properties independently from possible compensations encountered during assessment of test persons. This contribution discusses the development of an artificial foot enabling objective testing of the mechanical and functional properties of sports and leisure shoes.
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Artificially intelligent agents increasingly collaborate with humans in human-agent teams. Timely proactive sharing of relevant information within the team contributes to the overall team performance. This paper presents a machine learning approach to proactive communication in AI-agents using contextual factors. Proactive communication was learned in two consecutive experimental steps: (a) multi-agent team simulations to learn effective communicative behaviors, and (b) human-agent team experiments to refine communication suitable for a human team member. Results consist of proactive communication policies for communicating both beliefs and goals within human-agent teams. Agents learned to use minimal communication to improve team performance in simulation, while they learned more specific socially desirable behaviors in the human-agent team experiment
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Deze casestudie geeft inzicht in verschillende soorten kennis die kenmerkend zijn voor applied design research. Er wordt onderscheid gemaakt tussen kennis over de huidige situatie, over wenselijke alternatieven en over effectieve oplossingen om daar te komen. Ofwel, kennis hoe het is, kennis over hoe het kan zijn en kennis over hoe het zal zijn als we effectieve oplossingen toepassen. Elk van deze soorten kennis heeft andere kwaliteitscriteria.
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The 6th International Human Rights Education Conference is about teaching human rights. The purpose of this convention is to protect and promote the right of people with disabilities to participate equally in societal life. Implementation of the convention is a responsibility of the national government. At the Utrecht University of Applied Sciences a social work course now includes an introductory lecture on human rights using objects and a game that addresses the UN Convention on the Rights of Persons with Disabilities.
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Development of novel testing strategies to detect adverse human health effects is of interest to replace in vivo-based drug and chemical safety testing. The aim of the present study was to investigate whether physiologically based kinetic (PBK) modeling-facilitated conversion of in vitro toxicity data is an adequate approach to predict in vivo cardiotoxicity in humans. To enable evaluation of predictions made, methadone was selected as the model compound, being a compound for which data on both kinetics and cardiotoxicity in humans are available. A PBK model for methadone in humans was developed and evaluated against available kinetic data presenting an adequate match. Use of the developed PBK model to convert concentration–response curves for the effect of methadone on human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) in the so-called multi electrode array (MEA) assay resulted in predictions for in vivo dose–response curves for methadone-induced cardiotoxicity that matched the available in vivo data. The results also revealed differences in protein plasma binding of methadone to be a potential factor underlying variation between individuals with respect to sensitivity towards the cardiotoxic effects of methadone. The present study provides a proof-of-principle of using PBK modeling-based reverse dosimetry of in vitro data for the prediction of cardiotoxicity in humans, providing a novel testing strategy in cardiac safety studies.
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A substantial amount of studies have addressed the influence of sound on human performance. In many of these, however, the large acoustic differences between experimental conditions prevent a direct translation of the results to realistic effects of room acoustic interventions. This review identifies those studies which can be, in principle, translated to (changes in) room acoustic parameters and adds to the knowledge about the influence of the indoor sound environment on people. The review procedure is based on the effect room acoustics can have on the relevant quantifiers of the sound environment in a room or space. 272 papers containing empirical findings on the influence of sound or noise on some measure of human performance were found. Of these, only 12 papers complied with this review's criteria. A conceptual framework is suggested based on the analysis of results, positioning the role of room acoustics in the influence of sound on task performance. Furthermore, valuable insights are pre- sented that can be used in future studies on this topic. Whi le the influence of the sound environment on performance is clearly an issue in many situations, evidence regarding the effectiveness of strategies to control the sound environment by room acoustic design is lacking and should be a focus area in future studies.
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What options are open for peoplecitizens, politicians, and other nonscientiststo become actively involved in and anticipate new directions in the life sciences? In addressing this question, this article focuses on the start of the Human Genome Project (1985-1990). By contrasting various models of democracy (liberal, republican, deliberative), I examine the democratic potential the models provide for citizens' involvement in setting priorities and funding patterns related to big science projects. To enhance the democratizing of big science projects and give citizens opportunities to reflect, anticipate, and negotiate on newdirections in science and technology at a global level, liberal democracy with its national scope and representative structure does not suffice. Although republican (communicative) and deliberative (associative) democracy models meet the need for greater citizen involvement, the ways to achieve the ideal at a global level still remain to be developed.
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Both climate change and human activity are the important drivers that can change hydrological cycle routs and affect the features of hydrological drought in river basins. The current study selects the Zayandeh Rud river Basin as a case study region in which to evaluate the influences of climate alteration and human activity on meteorological and hydrological drought based on the Standardized Precipitation Index (SPI) and Standardized Runoff Index (SRI) on different time scales. The generated local climatic data of future years (2006–2040), (2041–2075) and (2076–2100) under the severest scenario (RCP 8.5) from the CMIP5 climate model are selected and used for the hydrology model and water allocation model of WEAP to construct hydrological drought which also consider human activities. The results indicate that significant meteorological drought is expected to occur in the winter and spring months of January to June. However, the driest month for hydrological drought is in the summer and autumn (July to December) (e.g. no changes in seasonality of droughts compared to historic period). It is concluded that, in the results of this work, the human influences on projected hydrological drought have been outlined; they had been missed in many projections for future hydrological drought. However, this study confirms the previous study (Bierkens et al. 2012) which mentioned that human influences can account for future hydrological drought in areas of Asia, the Middle East and the Mediterranean. The results attained in this study are beneficial for examining how hydrological drought characterizations respond to climate alteration and human activity on several time scales, thereby providing scientific information for drought predicting and water resources management over various time scales under non-stationary circumstances.
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