Voltaire wrote of the Frenchwoman Gabrielle Emilie Le Tonnelier that she was a great man, with only one fault, namely that she was a woman! She was a great mathematician, but being a woman she got little credit for that. She was not alone. This is truly a global problem that we must solve together! Being human is one, being female or male is just one quality, just like hair colour, body size or amount of pigment. Let 's transcend genders!
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The worldwide rise of skin cancer incidence rates increases the need to investigate ultraviolet radiation (UVR), as it is one of the main causes of skin cancer. 1 A ’ u to UVR varies depending on different factors such as the location of the individual and shielding effects. In this analysis, we evaluated wearables at different body positions measuring ultraviolet radiation when worn during daily activities at different locations. First, we analyzed which of the body positions provide the most robust measurements. We then devised a new measure, the horizon shielding factor, to evaluate the effect of horizon shielding and explored if high/low horizon shielding factor values coincide with particular geospatial attributes.
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Background: The substitution of healthcare is a way to control rising healthcare costs. The Primary Care Plus (PC+) intervention of the Dutch ‘Blue Care’ pioneer site aims to achieve this feat by facilitating consultations with medical specialists in the primary care setting. One of the specialties involved is dermatology. This study explores referral decisions following dermatology care in PC+ and the influence of predictive patient and consultation characteristics on this decision. Methods: This retrospective study used clinical data of patients who received dermatology care in PC+ between January 2015 and March 2017. The referral decision following PC+, (i.e., referral back to the general practitioner (GP) or referral to outpatient hospital care) was the primary outcome. Stepwise logistic regression modelling was used to describe variations in the referral decisions following PC+, with patient age and gender, number of PC+ consultations, patient diagnosis and treatment specialist as the predicting factors. Results: A total of 2952 patients visited PC+ for dermatology care. Of those patients with a registered referral, 80.2% (N = 2254) were referred back to the GP, and 19.8% (N = 558) were referred to outpatient hospital care. In the multivariable model, only the treating specialist and patient’s diagnosis independently influenced the referral decisions following PC+. Conclusion: The aim of PC+ is to reduce the number of referrals to outpatient hospital care. According to the results, the treating specialist and patient diagnosis influence referral decisions. Therefore, the results of this study can be used to discuss and improve specialist and patient profiles for PC+ to further optimise the effectiveness of the initiative.
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Deze publicatie is gemaakt om een overzicht te geven van de mogelijkheden van het toepassen van coatings op dunne metaalplaat. Naast deze publicatie verschijnen in het kader van het project "Nieuwe coatingtechnieken voor het MKB" nog vier andere publicaties die gezamenlijk een, zij het niet volledig, beeld geven van coatingtechnologie in het algemeen en de vele aspecten die daarmee samenhangen.
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Composietmaterialen zijn niet meer weg te denken uit de hedendaagse techniek. Niet alleen in de luchtvaart, maar ook in de bouwkunde, civiele techniek, transport en logistiek, scheepvaart, werktuigbouwkunde, en technische bedrijfskunde zal een (hbo) ingenieur vroeg of laat met deze materialen in aanraking komen. Dit boek geeft inzicht in de eigenschappen, vervaardigingsmethoden en ontwerpmethoden die onontbeerlijk zijn om volwaardige oplossingen vorm te geven door slim vezels en matrix te combineren.
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Background: Dermoscopy is known to increase the diagnostic accuracy of pigmented skin lesions (PSLs) when used by trained professionals. The effect of dermoscopy training on the diagnostic ability of dermal therapists (DTs) has not been studied so far. Objectives: This study aimed to investigate whether DTs, in comparison with general practitioners (GPs), benefited from a training programme including dermoscopy, in both their ability to differentiate between different forms of PSL and to assign the correct therapeutic strategy. Methods: In total, 24 DTs and 96 GPs attended a training programme on PSLs. Diagnostic skills as well as therapeutic strategy were assessed, prior to the training (pretest) and after the training (post-test) using clinical images alone, as well as after the addition of dermatoscopic images (integrated post-test). Bayesian hypothesis testing was used to determine statistical significance of differences between pretest, post-test and integrated post-test scores. Results: Both the DTs and the GPs demonstrated benefit from the training: at the integrated post-test, the median proportion of correctly diagnosed PSLs was 73% (range 30–90) for GPs and 63% (range 27–80) for DTs. A statistically significant difference between pretest results and integrated test results was seen, with a Bayes factor>100. At 12 percentage points higher, the GPs outperformed DTs in the accuracy of detecting PSLs. Conclusions: The study shows that a training programme focusing on PSLs while including dermoscopy positively impacts detection of PSLs by DTs and GPs. This training programme could form an integral part of the training of DTs in screening procedures, although additional research is needed.
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Abstract Background Dermoscopy is known to increase the diagnostic accuracy of pigmented skin lesions (PSLs) when used by trained professionals. The effect of dermoscopy training on the diagnostic ability of dermal therapists (DTs) has not been studied so far. Objectives This study aimed to investigate whether DTs, in comparison with general practitioners (GPs), benefited from a training programme including dermoscopy, in both their ability to differentiate between different forms of PSL and to assign the correct therapeutic strategy. Methods In total, 24 DTs and 96 GPs attended a training programme on PSLs. Diagnostic skills as well as therapeutic strategy were assessed, prior to the training (pretest) and after the training (post-test) using clinical images alone, as well as after the addition of dermatoscopic images (integrated post-test). Bayesian hypothesis testing was used to determine statistical significance of differences between pretest, post-test and integrated post-test scores. Results Both the DTs and the GPs demonstrated benefit from the training: at the integrated post-test, the median proportion of correctly diagnosed PSLs was 73% (range 30–90) for GPs and 63% (range 27–80) for DTs. A statistically significant difference between pretest results and integrated test results was seen, with a Bayes factor>100. At 12 percentage points higher, the GPs outperformed DTs in the accuracy of detecting PSLs. Conclusions The study shows that a training programme focusing on PSLs while including dermoscopy positively impacts detection of PSLs by DTs and GPs. This training programme could form an integral part of the training of DTs in screening procedures, although additional research is needed
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Synthetic ultra-black (UB) materials, which demonstrate exceptionally high absorbance (>99%) of visible light incident on their surface, are currently used as coatings in photovoltaic cells and numerous other applications. Most commercially available UB coatings are based on an array of carbon nanotubes, which are produced at relatively high temperature and result in numerous by-products. In addition, UB nanotube coatings require harsh application conditions and are very susceptible to abrasion. As a result, these coatings are currently obtained using a manufacturing process with relatively high costs, high energy consumption and low sustainability. Interestingly, an UB coating based on a biologically derived pigment could provide a cheaper and more sustainable alternative. Specifically, GLO Biotics proposes to create UB pigment by taking a bio-mimetic approach and replicate structures found in UB deep-sea fish. A recent study[1] has actually shown that specific fish have melanosomes in their skin with particular dimensions that allow absorption of up to 99.9% of incident light. In addition to this, recent advances in bacterial engineering have demonstrated that it is possible to create bacteria-derived melanin particles with very similar dimensions to the melanosomes in aforementioned fish. During this project, the consortium partners will combine both scientific observations in an attempt to provide the proof-of-concept for developing an ultra-black coating using bacteria-derived melanin particles as bio-based, sustainable pigment. For this, Zuyd University of Applied Sciences (Zuyd) and Maastricht University (UM) collaborate with GLO Biotics in the development of the innovative ‘BLACKTERIA’ UB coating technology. The partners will attempt at engineering an E. coli expression system and adapt its growth in order to produce melanin particles of desired dimensions. In addition, UM will utilize their expertise in industrial coating research to provide input for experimental set-up and the development of a desired UB coating using the bacteria-derived melanin particles as pigment.
Production of dry encapsulated forms of anthocyanins from tulip petals with high antioxidant activity and their utilization in lipsticks.Anthocyanins (of the Greek anthos = flower and kianos = blue) are the most important pigments of the plants. These pigments are responsible of the shiny orange, pink, red, violet and blue colors in the flowers and fruits of some plants. The most interesting substances of the waste material are anthocyanins as natural water soluble antioxidants with a great health benefit besides the coloring properties. Tulip is a perennial bulbous plant which is popular worldwide and especially in the Holland due to the showy flowers of the great variety of colors and shades. It was found that for flowers of different colors biosynthesis of anthocyanins of the three anthocyanidin backbones may occur. Thus, pelargonidin (Pg), cyanidin (Cy) and delphinidin (Dp) derivatives, are responsible for tulip flowers color.
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Fucoxanthine is een van de meest voorkomende carotenoïden en wordt voornamelijk geproduceerd door bruinwier en microalgen. Er is veel belangstelling voor de farmaceutische en cosmetische werking van fucoxanthine, zoals bescherming tegen UV-B geïnduceerd melanoom en huidveroudering. Desondanks zijn fucoxanthine extracten niet of nauwelijks verkrijgbaar als cosmetisch ingrediënt. Project FUCOS wil daarom zelf de productie van FUCOS extracten ontwikkelen en deze toepassen in cosmetische prototypen. Project FUCOS zal de fucoxanthine inhoud van commercieel beschikbare bruinwieren zoals Saccharina latissima en Undaria pinnatifida alsmede de microalg Isochrysis galbana evalueren om zo de meest rendabele biomassa grondstof te selecteren. Hier vanuit zullen kleinschalig verschillende groene, voedselveilige extractie methoden ontwikkeld en vergeleken worden op fucoxanthine opbrengst en kosten efficiëntie. De resulterende extracten kunnen worden toegepast in cosmetische prototypen na evaluatie van de biologische activiteiten. Hiermee zet project FUCOS een nieuwe stap richting de exploitatie van algen en wieren als biobased grondstof en de ontwikkeling van duurzame cosmetica.
