The Dutch government and leading academics in the field of circular economy propose that “repurposing”, i.e., finding new usages for discarded material, is important to reduce resource usage. Waste collectors, municipalities and start-ups increasingly find ways to develop circular business models, aiming for minimum loss of material integrity. Repurpose is a circular business model strategy which entails using a discarded product or its parts in a new product with a different function.The aim of this research is to gain a better understanding of this promising but academically underexposed circular strategy by empirically exploring its key characteristics and developing a taxonomy that reflects the scope and potential of the concept. The taxonomy development was based on clustering and comparing 96 case examples using key characteristics and critical factors empirically collected by means of 11 semi-structured expert interviews. The taxonomy was iteratively refined and validated by means of workshops with experts.This paper proposes a taxonomy and a comprehensive definition for repurposing. The Repurpose taxonomy distinguishes three main categories with increasing levels of material integrity: “Reprocess”, “Reshape” and “Recontextualize”. The taxonomy provides a refinement of existing circular business model patterns and frameworks for closing material loops strategies. It shows how repurposing may exploit the creative potential of design to fill the gap between reuse and recycling by retaining previously added value with three levels of physical adjustment.
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Laminated composites have important applications in modern aeronautical structures due to their extraordinary mechanical and environmental behaviour. Nevertheless, aircraft composite structures are highly vulnerable to impact damage, either by low-velocity sources during maintenance or high-velocity sources during in-flight events. Even barely visible impact damage induced by low-velocity loading, substantially reduces the residual mechanical performance and the safe-service life of the composites structures. Despite the extensive research already carried out, impact damage of laminated composite structures is still not well understood and it is an area of on-going research. Numerical modelling is considered as the most efficient tool as compared to the expensive and time-consuming experimental testing. In this paper, a finite element model based on explicit dynamics formulations is adopted. Hashin criterion is applied to predict the intra-laminar damage initiation and evolution. The numerical analysis is performed using the ABAQUS ® programme. The employed modelling approach is validated using numerical results found in the literature and the presented results show an acceptable correlation to the available literature data. It is demonstrated that the presented model is able to capture force-time response as well as damage evolution map for a range of impact energies.
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Fouling plays a major role in the Dairy industry. Five criteria: defined flow, no circulation, real factory product, defined product temperature and defined wall temperature, are used to review articles on this topic published between 2003 and 2020. To show the effect of those criteria in experiments, a simulation model is developed. For a good experimental design to measure fouling, the use of a dairy product in a tubular heater with a known developed flow is advised. The temperature-time history of the product and the wall temperature of the heater should be recorded. Circulation of a product will increase the fouling and decrease the flow. Although none of the reviewed articles complied to all criteria, 71% of the reviewed articles met at least two criteria. If not all criteria are met, the results are of less use for the application for process lines on industrial scale. A simulated computer model can be helpful.
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A loss of physical functioning (i.e., a low physical capacity and/or a low physical activity) is a common feature in patients with chronic obstructive pulmonary disease (COPD). To date, the primary care physiotherapy and specialized pulmonary rehabilitation are clearly underused, and limited to patients with a moderate to very severe degree of airflow limitation (GOLD stage 2 or higher). However, improved referral rates are a necessity to lower the burden for patients with COPD and for society. Therefore, a multidisciplinary group of healthcare professionals and scientists proposes a new model for referral of patients with COPD to the right type of exercise-based care, irrespective of the degree of airflow limitation. Indeed, disease instability (recent hospitalization, yes/no), the burden of disease (no/low, mild/moderate or high), physical capacity (low or preserved) and physical activity (low or preserved) need to be used to allocate patients to one of the six distinct patient profiles. Patients with profile 1 or 2 will not be referred for physiotherapy; patients with profiles 3–5 will be referred for primary care physiotherapy; and patients with profile 6 will be referred for screening for specialized pulmonary rehabilitation. The proposed Dutch model has the intention to get the right patient with COPD allocated to the right type of exercise-based care and at the right moment.
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Background: Profiling the plant root architecture is vital for selecting resilient crops that can efficiently take up water and nutrients. The high-performance imaging tools available to study root-growth dynamics with the optimal resolution are costly and stationary. In addition, performing nondestructive high-throughput phenotyping to extract the structural and morphological features of roots remains challenging. Results: We developed the MultipleXLab: a modular, mobile, and cost-effective setup to tackle these limitations. The system can continuously monitor thousands of seeds from germination to root development based on a conventional camera attached to a motorized multiaxis-rotational stage and custom-built 3D-printed plate holder with integrated light-emitting diode lighting. We also developed an image segmentation model based on deep learning that allows the users to analyze the data automatically. We tested the MultipleXLab to monitor seed germination and root growth of Arabidopsis developmental, cell cycle, and auxin transport mutants non-invasively at high-throughput and showed that the system provides robust data and allows precise evaluation of germination index and hourly growth rate between mutants. Conclusion: MultipleXLab provides a flexible and user-friendly root phenotyping platform that is an attractive mobile alternative to high-end imaging platforms and stationary growth chambers. It can be used in numerous applications by plant biologists, the seed industry, crop scientists, and breeding companies.
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The present study deals with the numerical modelling of hybridlaminated composites, which can be proved especially useful in theengineering and maintenance of advanced aerospace primary structures. Thelamina is comprised of continuous carbon fibers, thermosetting epoxypolymer matrix, as well as carbon nanostructures, such as graphene orcarbon nanotubes, inclusions. Halpin-Tsai equations combined with resultsobtained from nanomechanical analysis are employed in order to evaluatethe elastic properties of the carbon nanostructure/polymer matrix. Then, theobtained elastic properties of the hybrid matrix are used to calculate theorthotropic macro-mechanical properties of the unidirectional compositelamina. A hybrid composite plate is modelled as a 2D structure via theutilization of 4-node, quadrilateral, stress/displacement shell finite elementswith reduced integration formulation. The convergence and analysisaccuracy are tested. The mechanical performance of the hybrid compositesis investigated by considering specific configurations and applyingappropriate loading and boundary conditions. The results are compared withthe corresponding ones found in the open literature, where it is possible.
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Background Understanding the kinematic characteristics of relapse clubfoot compared to successfully treated clubfoot could aid early identification of a relapse and improve treatment planning. The usage of a multi segment foot model is essential in order to grasp the full complexity of the multi-planar and multi-joint deformity of the clubfoot. Research question The purpose of this study was to identify differences in foot kinematics, using a multi-segment foot model, during gait between patients with Ponseti treated clubfoot with and without a relapse and age-matched healthy controls. Methods A cross-sectional study was carried out including 11 patients with relapse clubfoot, 11 patients with clubfoot and 15 controls. Gait analysis was performed using an extended Helen Hayes model combined with the Oxford Foot Model. Statistical analysis included statistical parametric mapping and discrete analysis of kinematic gait parameters of the pelvis, hip, knee, ankle, hindfoot and forefoot in the sagittal, frontal and transversal plane. Results The relapse group showed significantly increased forefoot adduction in relation with the hindfoot and the tibia. Furthermore, this group showed increased forefoot supination in relation with the tibia during stance, whereas during swing increased forefoot supination in relation with the hindfoot was found in patients with relapse clubfoot compared with non-relapse clubfoot. Significance Forefoot adduction and forefoot supination could be kinematic indicators of relapse clubfoot, which might be useful in early identification of a relapse clubfoot. Subsequently, this could aid the optimization of clinical decision making and treatment planning for children with clubfoot.
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Publicatie ism TU Delft voor Proceedings of DESRIST 2018, 3-6 June, Madras, India. As digital technologies are transforming enterprises, the interest in business models is increasing. Technological disruptions like the Internet of Things (IoT) drive enterprises to redefine their business models to create and capture value, and eventually, to stay competitive. The need for business model innovation may be urgent, yet it is not always clear what to change in a business model. In these cases, business model exploration is needed. Within academia and practice, business model tools are mainly focused on formalizing single business model designs rather than facilitating systematic exploration of alternative business models. In this study, we present the design and prototype of a digital tool created to facilitate business model exploration. We use Design Science Research (DSR) as our research approach. In this paper, we present the results from the first cycle evaluation of the design and prototype.
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From teh UU repository: "Background: Oral immunotherapy (OIT) is a promising therapeutic approach to treat food allergic patients. However, there are some concerns regarding its safety and long-term efficacy. The use of non-digestible oligosaccharides might improve OIT efficacy since they are known to directly modulate intestinal epithelial and immune cells in addition to acting as prebiotics. Aim: To investigate whether a diet supplemented with plant-derived fructo-oligosaccharides (FOS) supports the efficacy of OIT in a murine cow's milk allergy model and to elucidate the potential mechanisms involved. Methods: After oral sensitization to the cow's milk protein whey, female C3H/HeOuJ mice were fed either a control diet or a diet supplemented with FOS (1% w/w) and received OIT (10 mg whey) 5 days a week for 3 weeks by gavage. Intradermal (i.d.) and intragastric (i.g.) challenges were performed to measure acute allergic symptoms and mast cell degranulation. Blood and organs were collected to measure antibody levels and T cell and dendritic cell populations. Spleen-derived T cell fractions (whole spleen-and CD25-depleted) were transferred to naive recipient mice to confirm the involvement of regulatory T cells (Tregs) in allergy protection induced by OIT + FOS. Results: OIT + FOS decreased acute allergic symptoms and mast cell degranulation upon challenge and prevented the challenge-induced increase in whey-specific IgE as observed in sensitized mice. Early induction of Tregs in the mesenteric lymph nodes (MLN) of OIT + FOS mice coincided with reduced T cell responsiveness in splenocyte cultures. CD25 depletion in OIT + FOS-derived splenocyte suspensions prior to transfer abolished protection against signs of anaphylaxis in recipients. OIT + FOS increased serum galectin-9 levels. No differences in short-chain fatty acid (SCFA) levels in the cecum were observed between the treatment groups. Concisely, FOS supplementation significantly improved OIT in the acute allergic skin response, %Foxp3+ Tregs and %LAP+ Th3 cells in MLN, and serum galectin-9 levels. Conclusion: FOS supplementation improved the efficacy of OIT in cow's milk allergic mice. Increased levels of Tregs in the MLN and abolished protection against signs of anaphylaxis upon transfer of CD25-depleted cell fractions, suggest a role for Foxp3+ Tregs in the protective effect of OIT + FOS. "
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