Objective: To prepare a set of statements for randomised clinical trials (RCT) integrity through an international multi-stakeholder consensus. Methods: The consensus was developed via: multi-country multidisciplinary stakeholder group composition and engagement; evidence synthesis of 55 systematic reviews concerning RCT integrity; anonymised two-round modified Delphi survey with consensus threshold based on the average percentage of majority opinions; and, a final consensus development meeting. Prospective registrations: (https://osf.io/bhncy, https://osf.io/3ursn). Results: There were 30 stakeholders representing 15 countries from five continents including triallists, ethicists, methodologists, statisticians, consumer representatives, industry representatives, systematic reviewers, funding body panel members, regulatory experts, authors, journal editors, peer-reviewers and advisors for resolving integrity concerns. Delphi survey response rate was 86.7% (26/30 stakeholders). There were 111 statements (73 stakeholder-provided, 46 systematic review-generated, 8 supported by both) in the initial long list, with eight additional statements provided during the consensus rounds. Through consensus the final set consolidated 81 statements (49 stakeholder-provided, 41 systematic review-generated, 9 supported by both). The entire RCT life cycle was covered by the set of statements including general aspects (n = 6), design and approval (n = 11), conduct and monitoring (n = 19), reporting of protocols and findings (n = 20), post-publication concerns (n = 12), and future research and development (n = 13). Conclusion: Implementation of this multi-stakeholder consensus statement is expected to enhance RCT integrity.
MULTIFILE
This positioning statement is written for the Centre of Expertise Healthy Ageing (CoE HA) and allied schools within the Hanze University of Applied Sciences. As focus for the coming years, the CoE HA has identified three themes, as well as three so-called ‘enablers’, i.e. approaches, methods and tools through which the themes can be developed concretely and implemented practically.
A transition to a circular economy is needed to revolutionize the construction sector and make it more sustainable for present and future generations. While the construction industry and the production of construction materials contribute to environmental pollution, they also offer great potential for addressing many environmental problems. Sheet materials are engineered wood boards that are produced from recycled or solid wood where an adhesive is used to bind the particles together, predominantly used in: Furniture manufacturing, Flooring application, Roofing, Wall sheathing. The most common binder for boards is urea-formaldehyde. Other binders may be used depending on the grade of board and its intended end-use. For example, melamine urea-formaldehyde, phenolic resins and polymeric diphenylmethane diisocyanate (PMDI) are generally used in boards that require improved moisture resistance. Formaldehyde is classified in the in the European Union as a carcinogen and it carries the hazard statement 'suspected of causing cancer'. In this project mycelium composites are developed as a formaldehyde-free, fully natural and biodegradable material with high potential to substitute these hazardous materials. The heat-press process, the feasibility of which was evaluated in a previous Kiem HBO project, is to be further developed towards a process where mycelium sheets with different thicknesses will be obtained. This is considered as a fundamental step to increase the material approachability to the market. Different Material manufacturing techniques are also considered to enable the increase of sample thicknesses and volume. Moreover, a business study will be incorporated to allow further understanding of the material market potential. The consortium composition of V8 Architects, QbiQ, Fairm, Verbruggen Paddestoelen BV, and CoEBBE merges different expertise and guarantees the consideration of the whole material production chain. The research will contribute to bring mycelium composites a step closer to the market, giving them visibility and increasing the possibility to a commercial breakthrough.
Met de start van het Nationaal Lectoren Platform Urban Energy (NL UE), ontstond een unieke nationale onderzoeksgroep voor toegepast onderzoek op het domein Urban Energy. Onze stip op de horizon, de realisatie van Netto energie neutrale steden in 2050, past bij het belang van hogescholen in de regio, de Regionale Energie Strategie (RES) en de wijkgerichte aanpak. De afgelopen jaren werkten we aan een gezamenlijke onderzoeksagenda, organiseerden, een studentenwedstrijd (Zero Energy Award) en deelden we kennis in 16 bijeenkomsten. Een website is ontwikkeld en online gezet (www.nlurbanenergy.nl). De komende jaren zetten we ons in voor: 1. De gezamenlijke onderzoeksagenda (afstemming binnen het platform en met anderen); 2. Uitwisseling van kennis en (nationale) actuele informatie tussen de lectoraten onderling; 3. Fieldlabs Urban Energy ontwikkelen in elke stad waar het platform vertegenwoordigd is; 4. Jaarlijks een conferentie, met demonstratie van onze projecten; 5. Profilering en positionering van toegepast onderzoek in de Nederlandse kennisinfrastructuur; 6. De samenwerking met LEVE, door profilering op de conferentie met impact van het hbo. We verwachten dat we met onze activiteiten op het domein van Urban Energy het praktijkgericht onderzoek van de Universities of Applied Sciences beter toegankelijk en de impact beter zichtbaar kunnen maken. De jaarlijkse conferentie is de plek waar we resultaten presenteren en delen met onze (inter)nationale omgeving. In de fieldlabs doen we dat voor onze regio en vergroten we de toegankelijkheid voor onze directe omgeving. De website ondersteunt dit heel laagdrempelig. Met het lectorenplatform Urban Energy versterken we met onze expertise de energietransitie in Nederland, dragen we bij aan de RES en wijkgerichte aanpak en versterken we de kennispositie van de hogescholen met directe impact in het praktijkgericht onderwijs en de beroepspraktijk.