In de richtlijnen van het Forensisch Medisch Genootschap is opgenomen dat het schatten van het tijdstip van overlijden onderdeel van de lijkschouw is. Het schatten van het tijdstip dient uitgevoerd te worden door de gemeentelijk lijkschouwer. Hierdoor valt te verwachten dat de forensisch arts als getuige-deskundige gehoord kan worden over het geschatte tijdstip van overlijden, dat in sommige strafzaken een cruciaal punt van discussie kan zijn. Uit ons retrospectieve onderzoek blijkt dat het tijdstip van overlijden, in 2013, in relatief weinig strafzaken een cruciale rol heeft gespeeld en dat in nog minder zaken een op wetenschappelijke literatuur gebaseerde methode aan de schatting ten grondslag lag.
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Falls are common after stroke. This article presents a literature review of the incidence and risk factors of falls and the consequences for professionals working with stroke patients. It is important to consider the specific problems after stroke. Depression and cognitive impairments were found to be risk factors for fall incidents after stroke. In the relevant literature many different risk factors and circumstances are described. When patients move from bed to chair, walk to the bathroom and the first few days after the patient is discharged to another setting, - all these circumstances showed high percentages of falling. A fall during hospital stay is a significant risk factor for future fall incidents. A reliable index to measure the fall risk is not (yet) available. But scores on the Barthel Index and the Timed-Up-and-Go test can be used as fall risk indicators. Fear of falling is an important complication after a fall and therefore it is recommended prior to discharge to inquire about the patients self efficacy in maintaining balance. Few intervention studies use the number of falls as an outcome measure. Exercising balance following a mass training protocol seems to diminish the risk of falling.
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BACKGROUND: The population of elderly patients with burn injuries is growing. Insight into long-term mortality rates of elderly after burn injury and predictors affecting outcome is limited. This study aimed to provide this information.METHODS: A multicentre observational retrospective cohort study was conducted in all three Dutch burn centres. Patients aged ≥65 years, admitted with burn injuries between 2009 and 2018, were included. Data were retrieved from electronic patient records and the Dutch Burn Repository R3. Mortality rates and standardized mortality ratios (SMRs) were calculated. Multivariable logistic regression was used to assess predictors for in-hospital mortality and mortality after discharge at 1 year and five-year. Survival analysis was used to assess predictors of five-year mortality.RESULTS: In total, 682/771 admitted patients were discharged. One-year and five-year mortality rates were 8.1 and 23.4%. The SMRs were 1.9(95%CI 1.5-2.5) and 1.4(95%CI 1.2-1.6), respectively. The SMRs were highest in patients aged 75-80 years at 1 year (SMRs 2.7, 95%CI 1.82-3.87) and five-year in patients aged 65-74 years (SMRs 10.1, 95%CI 7.7-13.0). Independent predictors for mortality at 1 year after discharge were higher age (OR 1.1, 95%CI 1.0-1.1), severe comorbidity, (ASA-score ≥ 3) (OR 4.8, 95%CI 2.3-9.7), and a non-home discharge location (OR 2.0, 95%CI 1.1-3.8). The relative risk of dying up to five-year was increased by age (HR 1.1, 95%CI 1.0-1.1), severe comorbidity (HR 2.3, 95%CI 1.6-3.5), and non-home discharge location (HR 2.1, 95%CI 1.4-3.2).CONCLUSION: Long-term mortality until five-year after burn injury was higher than the age and sex-matched general Dutch population, and predicted by higher age, severe comorbidity, and a non-home discharge destination. Next to pre-injury characteristics, potential long-lasting systemic consequences on biological mechanisms following burn injuries probably play a role in increased mortality. Decreased health status makes patients more prone to burn injuries, leading to early death.
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Doelstelling: In kaart brengen van de risicofactoren voor het ontwikkelen van binoculaire diplopie na conventionele monovisie door middel van contactlenzen of refractiechirurgie bij presbyopen. Methode: Voor deze literatuurstudie is in maart 2017 gezocht in databanken Pubmed, ScienceDirect en Google Scholar. Artikelen zijn geïncludeerd als binoculaire diplopie door monovisie wordt beschreven. Alle patiënten die worden weergegeven in deze artikelen zijn ouder dan 40 jaar en hebben monovisie door middel van contactlenzen of refractiechirurgie. De resultaten beschrijven de oorzaken van de binoculaire diplopie, de voorgeschiedenis van de patiënt met betrekking tot strabismus en de hoogte van additie. Onderscheid wordt gemaakt tussen contactlensdragers en patiënten die refractiechirurgie hebben ondergaan. Resultaten: In deze literatuurstudie zijn zes artikelen verwerkt. Uit deze artikelen zijn 35 patiënten met binoculaire diplopie meegenomen in dit onderzoek, vijftien patiënten met contactlens geïnduceerde monovisie en twintig patiënten met refractiechirurgie geïnduceerde monovisie. De oorzaken van binoculaire diplopie (decompensatie van een heteroforie, een intermitterend strabismus die constant wordt, een verworven heterotropie, decompensatie van een N IV parese en fixation switch diplopie) geven geen grote verschillen in aantal patiënten. Een additie hoger dan twee dioptrie komt meer voor in deze patiëntengroep met binoculaire diplopie dan een lagere additie. Een positieve voorgeschiedenis met betrekking tot strabismus komt meer voor dan een negatieve voorgeschiedenis. Relevante verschillen tussen contactlensdragers en patiënten die refractiechirurgie hebben ondergaan zijn niet gevonden. Conclusie: Vanwege het gebrek aan consistente data is meer onderzoek nodig voor significante resultaten.
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The promotor was Prof. Erik Jan Hultink and copromotors Dr Ellis van den Hende en Dr R. van der Lugt. The title of this dissertation is Armchair travelling the innovation journey. ‘Armchair travelling’ is an expression for travelling to another place, in the comfort of one’s own place. ‘The innovation journey’ is the metaphor Van de Ven and colleagues (1999) have used for travelling the uncharted river of innovation, the highly unpredictable and uncontrollable process of innovation. This research study began with a brief remark from an innovation project leader who sighed after a long and rough journey: ‘had I known this ahead of time…’. From wondering ‘what could he have known ahead of time?’ the immediate question arose: how do such innovation journeys develop? How do other innovation project leaders lead the innovation journey? And could I find examples of studies about these experiences from an innovation project leader’s perspective that could have helped the sighing innovation project leader to have known at least some of the challenges ahead of time? This dissertation is the result of that quest, as we do know relatively little how this process of the innovation project leader unfolds over time. The aim of this study is to increase our understanding of how innovation project leaders lead their innovation journeys over time, and to capture those experiences that could be a source for others to learn from and to be better prepared. This research project takes a process approach. Such an approach is different from a variance study. Process thinking takes into account how and why things – people, organizations, strategies, environments – change, act and evolve over time, expressed by Andrew Pettigrew (1992, p.10) as catching “reality in flight”.
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Patients with extensive and complex wounds due to Necrotizing Soft-Tissue Infections (NSTI) may be referred to a burn center. This study describes the characteristics, outcomes, as well as diagnostic challenges of these patients. Patients admitted to three hospitals with a burn center for the treatment of NSTI in a 5-year period were included. Eighty patients (median age 54 years, 60% male) were identified, of whom 30 (38%) were referred by other centers, usually after survival of the initial septic phase. Those referred from other centers, compared to those primarily admitted to the study hospitals, were more likely to have group A streptococcal involvement (62% vs 35%, p = .02), larger wounds (median 7% vs 2% total body surface area, p < .001), and a longer length of stay (median 49 vs 22 days, p < .001). Despite a high incidence of septic shock (50%), the mortality rate was low (12%) for those primarily admitted. Approximately half (53%) of the patients were initially misdiagnosed upon presentation, which was associated with delay to first surgery (16 hours vs 4 hours, p < .001). Those initially misdiagnosed had more (severe) comorbidities, and less frequently reported pain or blue livid discoloration of the skin. This study underlines the burn centers' function as referral centers for extensively affected patients with NSTI. Besides the unique wound and reconstructive expertise, the low mortality rate indicates these centers provide adequate acute care as well. A major remaining challenge remains recognition of the disease upon presentation. Future studies in which factors associated with misdiagnosis are explored are needed.
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Proefschrift ter verkrijging van de graad van doctor aan de Universiteit Utrecht op gezag van de rector magnificus, prof. dr. H.R.B.M. Kummeling, ingevolge het besluit van het college voor promoties in het openbaar te verdedigen op vrijdag 1 december 2023 des middags te 12.15 uur.
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BACKGROUND: Frailty is a predictor of adverse outcomes in elderly patients. The Canadian Study of Health and Aging Clinical Frailty Scale (CFS) is an often-used frailty assessment instrument. However, the CFS's reliability and validity in patients with burn injuries are unknown. This study aimed to assess the CFS's inter-rater reliability and validity (predictive validity, known group validity and convergent validity) in patients with burn injuries treated to specialized burn care.METHODS: A retrospective multicentre cohort study was conducted in all three Dutch burn centres. Patients aged ≥ 50 years with burn injuries, with a primary admission in 2015-2018, were included. Based on information in the electronic patient files, a research team member scored the CFS retrospectively. Inter-rater reliability was calculated using Krippendorff's α. Validity was assessed using logistic regression analysis. Patients with a CFS ≥ 5 were considered frail.RESULTS: In total, 540 patients were included, with a mean age of 65.8 years (SD 11.5) and a Total Body Surface Area (TBSA) burned of 8.5%. The CFS was used to assess frailty in 540 patients and the reliability of the CFS was scored for 212 patients. Mean CFS was 3.4(SD 2.0). Inter-rater reliability was adequate, Krippendorff's α 0.69 (95%CI 0.62-0.74). A positive frailty screening was predictive of a non-home discharge location (OR 3.57, 95%CI 2.16-5.93), a higher in-hospital mortality rate (OR 1.06-8.77), and a higher mortality rate within 12 months after discharge (OR 4.61, 95%CI 1.99-10.65) after adjustment for age, TBSA, and inhalation injury. Frail patients were more likely to be older (for<70 vs. ≥70 years odds ratio 2.88, 95%CI 1.95-4.25) and their comorbidities were more severe (ASA ≥3 vs 1-2 OR 6.43, 95%CI 4.26-9.70) (known group validity). The CFS was significantly related (rSpearman=0.55) to the Dutch Safety Management System (DSMS) frailty screening, reflecting a fair-good correlation between the CFS and DSMS frailty screening outcomes.CONCLUSION: The Clinical Frailty scale is reliable and has shown its validity, including its association with adverse outcomes in patients with burn injury admitted to specialized burn care. Early frailty assessment with the CFS must be considered, to optimize early recognition and treatment of frailty.
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BACKGROUND: Burn survivors are frequently faced with disfiguring scars. Various techniques exist to improve scar appearance, such as laser treatment and dermabrasion. Next to that, surgical reconstruction, such as scar excision is an option. This randomized controlled trial investigates whether a larger burn scar can be excised using a skin-stretching device for wound closure, thereby optimizing use of adjacent healthy skin. This technique may allow scar excision in a one-step procedure instead of two or more steps, which is necessary for serial excision and tissue expansion.METHODS: Two arms were compared: scar excision and closure by skin stretch and scar excision without additional techniques. The primary outcome measure was scar surface area reduction. In addition, complications were registered.RESULTS: Fifteen patients were randomized for skin stretch and 15 patients were randomized for scar excision only. In the skin stretch group, 10 of 15 scars were completely excised compared with three of 15 in the scar excision-only group (p = 0.025). In the skin stretch group, a significantly larger reduction in scar area was achieved: 95 ± 11 percent of the scar was excised versus 78 ± 17 percent in the scar excision-only group (p = 0.003). One patient in the skin stretch group and three patients in the scar excision-only group experienced partial wound dehiscence (p = 0.598).CONCLUSIONS: In burn scar reconstructions, a significantly larger reduction in scar area can be achieved using a skin-stretching device compared with scar excision with no additional techniques, without an increased risk of complications. It was shown that skin stretching is of added value for scars that cannot be excised in a one-step procedure.
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Het versterken van de leesvaardigheid is een prioriteit voor de Nederlandse overheid, omdat goed tekstbegrip essentieel is voor het leren en voor het functioneren in de maatschappij. Onderzoek wijst uit dat Nederlandse jongeren minder vaardig en minder graag lezen, waardoor effectieve leeslessen nodig zijn. In lees- en literatuurlessen Nederlands (en lessen in moderne vreemde talen) ligt de nadruk vaak op het beantwoorden van vragen over teksten, met weinig aandacht voor het lezen en begrijpen van literaire teksten zoals poëzie. Dit is een gemiste kans, omdat het lezen van dergelijke teksten de leesvaardigheid en het begrip van taal en cultuur kan vergroten. In dit onderzoek is voor het eerst onderzocht hoe havo- en vwo-leerlingen poëzie lezen en begrijpen in vergelijking met proza (korte verhalen en beschrijvende teksten), met behulp van tekst-met-vragen en oogbewegingstechnologie. Een eerste bevinding is dat de leesprestaties voor poëzie consistent lager zijn dan voor proza in alle leerjaren. Daarnaast verbetert het begrip van poëzie niet in de loop van de leerjaren, terwijl het begrip van proza dat wel doet. De eyetracking gegevens laten met name zien dat leerlingen zowel poëzie als proza de eerste keer snel en lineair (oppervlakkig) lezen, maar poëzieteksten langer lezen na het lezen van een vraag. Vervolgens werd een leesprogramma voor poëzie en proza ontwikkeld en getest. Het programma is gebaseerd op observerend leren aan de hand van video's van de oogbewegingen van leerlingen. Leerlingen die deelnamen aan het programma lazen en begrepen poëzie, korte verhalen en informatieve teksten significant beter, ook in vergelijking met leerlingen die reguliere leeslessen volgden. Het is daarom aan te bevelen om in lessen Nederlands en in andere lessen aandacht te besteden aan het leesproces van leerlingen, met name poëzie.
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