This study presents a methodology designed to optimize various parameters of each access point within a Multiple-Input Single-Output (MISO) Visible Light Communication (VLC) system. The primary objective is to enhance both power and spectral efficiencies. A MISO-VLC model is presented based on experimental evaluations and a problem formulation considering intermodulation distortions based on Orthogonal Frequency Division Multiplexing modulation. A Hybrid Multi-Objective Optimization (HMO) approach is proposed, combining the Non-Sorting Genetic Algorithm III (NSGA-III) and the Multi-objective Grey Wolf Optimization (MOGWO). The proposed HMO's success was validated by a 66 % reduction in transmitted power, maintaining the Error Vector Magnitude (EVM) performance metrics even at lower power transmission levels and minimizing the guard band to its lower bound.