This is the first draft of the large scale 3d printing protocol for granulated thermoplastics. The main purpose of this document is to share the key steps of operating, preparation, data entry, and optimization procedures while handling the robotic 3d printing equipment. One main aspect of this protocol is that it is independent of specific 3d printing hardware or software setups. The aim is to have the users from robotic 3d printing from various technologies follow these steps and be able to set the basics up when it comes to handling such 3d printers.
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Background: Cervical dystonia is characterized by involuntary muscle contractions of the neck and abnormal head positions that affect daily life activities and social life of patients. Patients are usually treated with botulinum toxin injections into affected neck muscles to relief pain and improve control of head postures. In addition, many patients are referred for physical therapy to improve their ability to perform activities of daily living. A recent review on allied health interventions in cervical dystonia showed a lack of randomized controlled intervention studies regarding the effectiveness of physical therapy interventions.Methods/design: The (cost-) effectiveness of a standardized physical therapy program compared to regular physical therapy, both as add-on treatment to botulinum toxin injections will be determined in a multi-centre, single blinded randomized controlled trial with 100 cervical dystonia patients. Primary outcomes are disability in daily functioning assessed with the disability subscale of the Toronto Western Spasmodic Torticollis Rating Scale. Secondary outcomes are pain, severity of dystonia, active range of motion of the head, quality of life, anxiety and depression. Data will be collected at baseline, after six months and one year by an independent blind assessor just prior to botulinum toxin injections. For the cost effectiveness, an additional economic evaluation will be performed with the costs per quality adjusted life-year as primary outcome parameter.Discussion: Our study will provide new evidence regarding the (cost-) effectiveness of a standardized, tailored physical therapy program for patients with cervical dystonia. It is widely felt that allied health interventions, including physical therapy, may offer a valuable supplement to the current therapeutic options. A positive outcome will lead to a greater use of the standardized physical therapy program. For the Dutch situation a positive outcome implies that the standardized physical therapy program forms the basis for a national treatment guideline for cervical dystonia.Trial registration: Number Dutch Trial registration (Nederlands Trial Register): NTR3437.
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Vanuit Fontys Hogescholen wordt veel onderzoek gedaan, met name door onderzoekers van de verschillende lectoraten. Vanzelfsprekend worden er binnen deze onderzoeken veel data verzameld en verwerkt. Fontys onderschrijft het belang van zorgvuldige omgang met onderzoeksdata en vraagt daarom van onderzoekers dat zij hun Research Data Management (RDM) op orde hebben. Denk hierbij aan veilige opslag en duurzame toegankelijkheid van data. Maar ook (open access) publiceren en archiveren van onderzoeksdata maken onderdeel uit van RDM. Hoe je hier als onderzoeker invulling aan geeft kan soms best een zoektocht zijn, mede doordat nog niet iedereen even bekend is met het onderwerp RDM. Met dit boek hopen we onderzoekers binnen Fontys de belangrijkste informatie te bieden die nodig is om goed invulling te geven aan Research Data Management en daarbij ook te wijzen op de ondersteuning die op dit gebied voorhanden is.
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Organ-on-a-chip technology holds great promise to revolutionize pharmaceutical drug discovery and development which nowadays is a tremendously expensive and inefficient process. It will enable faster, cheaper, physiologically relevant, and more reliable (standardized) assays for biomedical science and drug testing. In particular, it is anticipated that organ-on-a-chip technology can substantially replace animal drug testing with using the by far better models of true human cells. Despite this great potential and progress in the field, the technology still lacks standardized protocols and robust chip devices, which are absolutely needed for this technology to bring the abovementioned potential to fruition. Of particular interest is heart-on-a-chip for drug and cardiotoxicity screening. There is presently no preclinical test system predicting the most important features of cardiac safety accurately and cost-effectively. The main goal of this project is to fabricate standardized, robust generic heart-on-a-chip demonstrator devices that will be validated and further optimized to generate new physiologically relevant models to study cardiotoxicity in vitro. To achieve this goal various aspects will be considered, including (i) the search for alternative chip materials to replace PDMS, (ii) inner chip surface modification and treatment (chemistry and topology), (iii) achieving 2D/3D cardiomyocyte (long term) cell culture and cellular alignment within the chip device, (iv) the possibility of integrating in-line sensors in the devices and, finally, (v) the overall chip design. The achieved standardized heart-on-a-chip technology will be adopted by pharmaceutical industry. This proposed project offers a unique opportunity for the Netherlands, and Twente in particular, which has relevant expertise, potential, and future perspective in this field as it hosts world-leading companies pioneering various core aspects of the technology that are relevant for organs-on-chips, combined with two world-leading research institutes within the University of Twente.
Climate change and the depletion of resources in the world are widely recognized as the greatest societal challenges. The building sector is responsible for 40% of the raw material consumption globally. The emissions related to construction materials are anticipated to double by 2050, if no new technologies are adopted (EC, 2021). Based on the environmental cost indicator, isolation has the second largest (after concrete) impact to the environment. In Mythic - Myterials for THermal Insulation in Construction goal is to develop (in co-creation with the work field) the best available mycelium biocomposite, which can be used as a circular, biodegradable insulation material for construction in the building sector. In recent research projects partners concluded that Mycelium biocomposites have a high potential to replace traditional fossil-based isolation materials, but further research on the thermal insulation and moisture absorption is needed to convince the construction market. In the project various partners will cooperate, both from the production side of mycelium composites, as well as from the application side. Some partners originate from previous projects, but others contacted Centre of Expertise for the Biobased Economy (CoEBBE) to build further on the existing network. There are several SME’s from the Netherlands, but also from abroad (Nylausn from Iceland, Mogu Srl from Italy and Corstyrene form France), as well as Branche organizations and knowledge institutes. Avans works together with HZ in CoEBBE and for the microbiological knowledge we cooperate with the University of Utrecht. For the market research CoEBBE cooperates with the lectorate New Marketing within Avans, focussing on sustainability via biomimicry. Mycelium composites and natural products for the building industry is the theme that binds all partners.
