Companies in the Brainport region are often characterized as high mix low volume (HMLV) production environments. These companies are distinguished by a wide range of possible products (high product variety), which are produced in low volumes. These are often customer-specific products that are produced once or incidentally. Traditionally, these companies focus on efficient use of resources, where utilisation rate and cost coverage are relevant. The increasing customer demand in the region leads to pressure on production capacity. An initial intuitive response from these companies is to further increase the utilisation rate of machines. To keep costs manageable, the company tries to avoid investing in additional capacity. An undesirable side effect is increasing pressure on timeliness (delivery, such as lead times, delivery reliability, flexibility) and quality. The apparent contradiction between costs and timeliness in these HMLV production environments is a recurring issue in practice-oriented research conducted by Fontys Industrial Engineering and Management students. This results in the following research question: Which sub-aspects may be relevant to the performance regarding Quality, Delivery, and Cost (QDC) of an HMLV production environment?
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There are three volumes in this body of work. In volume one, we lay the foundation for a general theory of organizing. We propose that organizing is a continuous process of ongoing mutual or reciprocal influence between objects (e.g., human actors) in a field, whereby a field is infinite and connects all the objects in it much like electromagnetic fields influence atomic and molecular charged objects or gravity fields influence inanimate objects with mass such as planets and stars. We use field theory to build what we now call the Network Field Model. In this model, human actors are modeled as pointlike objects in the field. Influence between and investments in these point-like human objects are explained as energy exchanges (potential and kinetic) which can be described in terms of three different types of capital: financial (assets), human capital (the individual) and social (two or more humans in a network). This model is predicated on a field theoretical understanding about the world we live in. We use historical and contemporaneous examples of human activity and describe them in terms of the model. In volume two, we demonstrate how to apply the model. In volume 3, we use experimental data to prove the reliability of the model. These three volumes will persistently challenge the reader’s understanding of time, position and what it means to be part of an infinite field. http://dx.doi.org/10.5772/intechopen.99709
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BackgroundPhysical exercise in cancer patients is a promising intervention to improve cognition and increase brain volume, including hippocampal volume. We investigated whether a 6-month exercise intervention primarily impacts total hippocampal volume and additionally hippocampal subfield volumes, cortical thickness and grey matter volume in previously physically inactive breast cancer patients. Furthermore, we evaluated associations with verbal memory.MethodsChemotherapy-exposed breast cancer patients (stage I-III, 2–4 years post diagnosis) with cognitive problems were included and randomized in an exercise intervention (n = 70, age = 52.5 ± 9.0 years) or control group (n = 72, age = 53.2 ± 8.6 years). The intervention consisted of 2x1 hours/week of supervised aerobic and strength training and 2x1 hours/week Nordic or power walking. At baseline and at 6-month follow-up, volumetric brain measures were derived from 3D T1-weighted 3T magnetic resonance imaging scans, including hippocampal (subfield) volume (FreeSurfer), cortical thickness (CAT12), and grey matter volume (voxel-based morphometry CAT12). Physical fitness was measured with a cardiopulmonary exercise test. Memory functioning was measured with the Hopkins Verbal Learning Test-Revised (HVLT-R total recall) and Wordlist Learning of an online cognitive test battery, the Amsterdam Cognition Scan (ACS Wordlist Learning). An explorative analysis was conducted in highly fatigued patients (score of ≥ 39 on the symptom scale ‘fatigue’ of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire), as previous research in this dataset has shown that the intervention improved cognition only in these patients.ResultsMultiple regression analyses and voxel-based morphometry revealed no significant intervention effects on brain volume, although at baseline increased physical fitness was significantly related to larger brain volume (e.g., total hippocampal volume: R = 0.32, B = 21.7 mm3, 95 % CI = 3.0 – 40.4). Subgroup analyses showed an intervention effect in highly fatigued patients. Unexpectedly, these patients had significant reductions in hippocampal volume, compared to the control group (e.g., total hippocampal volume: B = −52.3 mm3, 95 % CI = −100.3 – −4.4)), which was related to improved memory functioning (HVLT-R total recall: B = −0.022, 95 % CI = −0.039 – −0.005; ACS Wordlist Learning: B = −0.039, 95 % CI = −0.062 – −0.015).ConclusionsNo exercise intervention effects were found on hippocampal volume, hippocampal subfield volumes, cortical thickness or grey matter volume for the entire intervention group. Contrary to what we expected, in highly fatigued patients a reduction in hippocampal volume was found after the intervention, which was related to improved memory functioning. These results suggest that physical fitness may benefit cognition in specific groups and stress the importance of further research into the biological basis of this finding.
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The objective of CW4N is to identify opportunities for wood reuse through the use of advanced digital production technologies1, and develop related implementation strategies for public organisations, in particular housing corporations and municipalities. Strategies include concrete proposals on how to: a) collect and process wood waste from residential buildings; b) add value to reclaimed wood by means of digital production; c) increase tenant involvement and acceptance for waste wood collection and circular reuse; d) create impactful applications for a circular economy. The research is carried out in four work packages. The first identifies the nature of residential wood waste (volume, type, application) from past case projects of housing corporations Ymere and Rochdale. Their upcoming renovation plans are evaluated, to identify resources and hotspots for future implementations. The second workpackage explores what applications can be conceived, given the available wood and digital production tools at the AUAS Robot Lab. In the third workpackage case studies are carried out for actual projects of the housing corporations. Physical prototypes are used as conversation pieces to involve tenants and increase their acceptance for circular applications. In the fourth workpackage all findings are combined in a set of implementation strategies. High-quality data-collection is crucial for the project, since it will determine the nature of the materials for designing and manufacturing applications. In this proposal, additional resources are added to the project to take care of data-collection. Due to covid-19, project managers at Ymere and Rochdale must focus on day-to-day work to get ongoing and planned building projects done, reducing their time for data collection from previous projects. In addition, because of teleworking, non-digital data such as drawings and reports are not easily accessible. To enhance data-collection, student-assistants will be added to the project to survey ongoing renovation projects in the field.
The EU Climate and Energy Policy Framework targets a 40% reduction in Greenhouse Gases (GHGs) emission by companies (when compared to 1990’s values) in 2030 [1]. Preparing for that future, many companies are working to reach climate neutrality in 2030. For water and wastewater treatment plants aeration processes could represent up to 70% of the whole energy consumption of the plant. Thus, a process which must be carefully evaluated if climate neutrality is a target. VortOx is an alternative to reduce power consumption in aeration processes. It is structured to test the applicability of geometrically constrained vortices in a hyperbolic funnel (aka “Schauberger”- funnel) as an innovative aeration technique for this industry. Recent investigations have shown that such systems allow an average of 12x more oxygen transfer coefficients (KLa) than that of comparable methods like air jets or impellers [10]. However, the system has a relatively small hydraulic retention time (HRT), which compromises its standard oxygen transfer ratio (SOTR). Additionally, so far, the system has only been tested in pilot (lab) scale. Vortox will tackle both challenges. Firstly, it will test geometry and flow adaptations to increase HRT keeping the same KLa levels. And secondly, all will be done using a real scale hyperbolic funnel and real effluent from Leeuwarden’s wastewater treatment plant demo-site. If proven feasible, Vortox can be a large step towards climate neutral water and wastewater treatment systems.
