Obesity, especially morbid obesity, is a major health problem with considerable impact on physical, mental and social quality of life. Assessment of quality of life is considered crucial to understand and evaluate the consequences of obesity. Obesity has major consequences for quality of life, e.g., as a result of co-morbidities of obesity and weight stigmatization.Bariatric surgery has been proven to lead to significant weight loss and improvement of quality of life. Besides obesity, also personal and psychosocial variables influence quality of life and affect the outcome of surgery. Moreover, obesity, even after substantial weight loss by gastric bypass surgery, is a chronic disease requiring life long consideration, in order to sustain long standing quality of life improvement.