In order to accept and implement technology in a successful manner, not only determinants (acceptance barriers or facilitators) related to individual persons, for instance, health care providers as well as health care recipients, are important. Also interpersonal relationships on the work floor as well as the readiness and support of the organization itself are involved in the process of uptake of innovations. The Normalization Process Theory explains how this can be understood. The Technology Adoption Readiness Scale (TARS), developed based on this theory, offers a tool to diagnose the opportunities and challenges in health care organizations with respect to the implementation of certain technology- or eHealth applications. In order to guide the process of large scale implementation of technological innovations, also a pre implementation diagnosis is useful. This diagnosis, when provided by a “neutral party” has proved to be helpful for monitoring, guiding and thus supporting the implementation process of technological innovations in health care settings.