The case studies upon which this chapter was built were predominantly written during 2020, based upon the Rubin and Guth survey data drawn from the 2018–2019 university academic year and additional data provided by the six case study contributors in 2020. Our analysis began during the latter part of 2020 and was completed by mid-2021, while the effects of the pandemic on the growth of COIL were becoming increasingly evident. We have updated the course number data through the academic year 2020–2021 for the cases presented. Additionally, there are sidebars from some of the contributors discussing what took place at their institution since the COVID-19 pandemic struck.