Light therapy is increasingly administered and studied as a non-pharmacologic treatment for a variety of healthrelated problems, including treatment of people with dementia. Light therapy comes in a variety of ways, ranging from being exposed to daylight, to being exposed to light emitted by light boxes and ambient bright light. Light therapy is an area in medicine where medical sciences meet the realms of physics, engineering and technology. Therefore, it is paramount that attention is paid in the methodology of studies to the technical aspects in their full breadth. This paper provides an extensive introduction for non-technical researchers on how to describe and adjust their methodology when involved in lighting therapy research. A specific focus in this manuscript is on ambient bright light, as it is an emerging field within the domain of light therapy. The paper deals with how to (i) describe the lighting equipment, (ii) describe the light measurements, (iii) describe the building and interaction with daylight. Moreover, attention is paid to the uncertainty in standards and guidelines regarding light and lighting for older adults.
Background & aims: Optimal nutritional support during the acute phase of critical illness remains controversial. We hypothesized that patients with low skeletal muscle area and -density may specifically benefit from early high protein intake. Aim of the present study was to determine the association between early protein intake (day 2–4) and mortality in critically ill intensive care unit (ICU) patients with normal skeletal muscle area, low skeletal muscle area, or combined low skeletal muscle area and -density. Methods: Retrospective database study in mechanically ventilated, adult critically ill patients with an abdominal CT-scan suitable for skeletal muscle assessment around ICU admission, admitted from January 2004 to January 2016 (n = 739). Patients received protocolized nutrition with protein target 1.2–1.5 g/kg/day. Skeletal muscle area and -density were assessed on abdominal CT-scans at the 3rd lumbar vertebra level using previously defined cut-offs. Results: Of 739 included patients (mean age 58 years, 483 male (65%), APACHE II score 23), 294 (40%) were admitted with normal skeletal muscle area and 445 (60%) with low skeletal muscle area. Two hundred (45% of the low skeletal muscle area group) had combined low skeletal muscle area and -density. In the normal skeletal muscle area group, no significant associations were found. In the low skeletal muscle area group, higher early protein intake was associated with lower 60-day mortality (adjusted hazard ratio (HR) per 0.1 g/kg/day 0.82, 95%CI 0.73–0.94) and lower 6-month mortality (HR 0.88, 95%CI 0.79–0.98). Similar associations were found in the combined low skeletal muscle area and -density subgroup (HR 0.76, 95%CI 0.64–0.90 for 60-day mortality and HR 0.80, 95%CI 0.68–0.93 for 6-month mortality). Conclusions: Early high protein intake is associated with lower mortality in critically ill patients with low skeletal muscle area and -density, but not in patients with normal skeletal muscle area on admission. These findings may be a further step to personalized nutrition, although randomized studies are needed to assess causality.
Behavioural and psychological symptoms, such as nocturnal restlessness and wandering, are seen in 90% of patients with dementia at some point in their course. Non-pharmacologic interventions, such as high-intensity lighting, can play an important role in managing these behavioural and psychological symptoms by impacting both the visual and the circadian system. In order to assess the effects of prolonged exposure to high-intensity light (about 1800 lx horizontal on table level) on behaviour and circadian rhythmicity of institutionalised older adults with dementia, ceiling-mounted luminaires emitting bluish (6500 K) and yellowish (2700 K) light were installed in an intervention group that was compared to a control group of traditional dim lighting equipment. The study was performed from May to August 2006. Effects of the lighting intervention were assessed by the Dutch Behaviour Observation Scale for Intramural Psychogeriatrics (GIP), and tympanic temperature measurements. In the bluish light scenario, a significant improvement in restless behaviour was observed in the intervention group, as well as a significant increase in the range of tympanic temperature. These effects were not found in the yellowish light scenario. Further evidence is found that high-intensity bluish light may play a role in managing restless behaviour and improving circadian rhythmicity in institutionalised older adults with dementia.
In this project, the AGM R&D team developed and refined the use of a facial scanning rig. The rig is a physical device comprising multiple cameras and lighting that are mounted on scaffolding around a 'scanning volume'. This is an area at which objects are placed before being photographed from multiple angles. The object is typically a person's head, but it can be anything of this approximate size. Software compares the photographs to create a digital 3D recreation - this process is called photogrammetry. The 3D model is then processed by further pieces of software and eventually becomes a face that can be animated inside in Unreal Engine, which is a popular piece of game development software made by the company Epic. This project was funded by Epic's 'Megagrant' system, and the focus of the work is on streamlining and automating the processing pipeline, and on improving the quality of the resulting output. Additional work has been done on skin shaders (simulating the quality of real skin in a digital form) and the use of AI to re/create lifelike hair styles. The R&D work has produced significant savings in regards to the processing time and the quality of facial scans, has produced a system that has benefitted the educational offering of BUas, and has attracted collaborators from the commercial entertainment/simulation industries. This work complements and extends previous work done on the VIBE project, where the focus was on creating lifelike human avatars for the medical industry.
Er wordt continu ‘reuzenarbeid’ verricht in het rivierengebied in het teken van hoogwaterbescherming, vaarwegbeheer, natuurontwikkeling en delfstoffenwinning. Bij veel van deze rivierprojecten maakt grondverzet het grootste deel uit. Het is onder andere bepalend voor de kosten, de CO2-footprint en de omgevingshinder van dergelijke projecten, en de ruimtelijke kwaliteit van het rivierlandschap. Slim omgaan met grond is daarom een sleutelfactor van duurzaam rivierbeheer. Het onderwerp heeft daarom een prominente plek in verschillende kennis- en innovatieagenda’s, zoals de KIA Landbouw, Voedsel en Water, de KIA Circulaire Economie, en de KIA van het Hoogwaterbeschermingsprogramma. Deze articuleren een behoefte aan praktijkgericht onderzoek dat bijdraagt aan verduurzaming en kostenreductie van grondverzet, zodat grondverzet in 2030 energieneutraal is, de kosten per m3 tussen 2020 en 2030 aanzienlijk gedaald zijn en dat er in 2030 een gezonde slibeconomie is voor circulair materiaalgebruik. Desondanks moet er nog heel wat water door de Rijn voordat bovenstaande ambities in de praktijk kunnen worden gehaald. Het doel van dit project is om praktische inzichten en tools voor duurzaam grondmanagement in riviergebieden te ontwikkelen. Een consortium van 22 partijen (publiek, privaat, kennis) zal onder leiding van HAN lectoraat Sustainable River Management praktijkgericht onderzoek doen ter ondersteuning van technisch managers, ontwerpers, risicomanagers, projectmanagers en beheerders van dijken en uiterwaarden. Door middel van o.a. materiaalonderzoek, ontwerpend onderzoek en evaluaties worden praktische handvatten ontwikkeld voor realisatiestrategieën voor grondstoffenwinning volgens het DNA van de rivier, en het bruikbaar maken van sediment en gebiedseigen grond voor toepassing in de dijkenbouw. Bovendien worden verbeterde werkwijzen en tools ontwikkeld voor het op riviertakniveau afstemmen van vraag en aanbod van delfstoffen in natuur- en dijkversterkingsprojecten in het rivierengebied. Hiermee levert het project een concrete bijdrage aan de invulling van het Grondstoffenakkoord en het Rijksprogramma ‘Nederland Circulair in 2050’.
