Deze publicatie bevat de belangrijkste bevindingen van een verkenning van de kansen die de inzet van retail en cultuur bieden voor de ontwikkeling van kwaliteit in binnensteden. Een groot aantal gemeenten wordt geconfronteerd met vraagstukken over de herinrichting van zowel hun kernen als de omliggende wijken en gebieden. Tegelijkertijd geldt dat zowel retail als cultuur zich voor belangrijke uitdagingen gesteld zien in het postcorona tijdperk. In ‘Verbinding als sleutel tot stedelijke kwaliteit’ wordt de problematiek uiteengezet, de kansen en mogelijkheden van een ontwerpbenadering toegelicht en een tweetal cases behandeld: Hart van Zuid in Rotterdam en Osdorpplein in Amsterdam.
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Background: Adverse outcome pathway (AOP) networks are versatile tools in toxicology and risk assessment that capture and visualize mechanisms driving toxicity originating from various data sources. They share a common structure consisting of a set of molecular initiating events and key events, connected by key event relationships, leading to the actual adverse outcome. AOP networks are to be considered living documents that should be frequently updated by feeding in new data. Such iterative optimization exercises are typically done manually, which not only is a time-consuming effort, but also bears the risk of overlooking critical data. The present study introduces a novel approach for AOP network optimization of a previously published AOP network on chemical-induced cholestasis using artificial intelligence to facilitate automated data collection followed by subsequent quantitative confidence assessment of molecular initiating events, key events, and key event relationships. Methods: Artificial intelligence-assisted data collection was performed by means of the free web platform Sysrev. Confidence levels of the tailored Bradford-Hill criteria were quantified for the purpose of weight-of-evidence assessment of the optimized AOP network. Scores were calculated for biological plausibility, empirical evidence, and essentiality, and were integrated into a total key event relationship confidence value. The optimized AOP network was visualized using Cytoscape with the node size representing the incidence of the key event and the edge size indicating the total confidence in the key event relationship. Results: This resulted in the identification of 38 and 135 unique key events and key event relationships, respectively. Transporter changes was the key event with the highest incidence, and formed the most confident key event relationship with the adverse outcome, cholestasis. Other important key events present in the AOP network include: nuclear receptor changes, intracellular bile acid accumulation, bile acid synthesis changes, oxidative stress, inflammation and apoptosis. Conclusions: This process led to the creation of an extensively informative AOP network focused on chemical-induced cholestasis. This optimized AOP network may serve as a mechanistic compass for the development of a battery of in vitro assays to reliably predict chemical-induced cholestatic injury.
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Dit wetenschappelijk artikel beschrijft het protocol van de GET READY studie. Deze studie is ontwikkeld voor mensen die een angststoornis of depressie hebben gehad, en dient als terugvalpreventie interventie. De interventie bestaat uit online modules, monitoring en contacten met een POH-GGZ. De achtergrond van terugvalpreventie wordt toegelicht, de methoden van de studie worden gedetailleerd beschreven en er wordt vooruit gekeken naar hoe deze studie een bijdrage kan leveren in het veld van terugvalpreventie.
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The Smart Current Limiter is a switching DC to DC converter that provides a digitally pre-set input current control for inrush limiting and power management. Being able to digitally adjust the current level in combination with external feedback can be used for control systems like temperature control in high power DC appliances. Traditionally inrush current limiting is done using a passive resistance whose resistance changes depending on the current level. Bypassing this inrush limiting resister with a Mosfet improves efficiency and controllability, but footprint and losses remain large. A switched current mode controlled inrush limiter can limit inrush currents and even control the amount of current passing to the application. This enables power management and inrush current limitation in a single device. To reduce footprint and costs a balance between losses and cost-price on one side and electromagnetic interference on the other side is sought and an optimum switching frequency is chosen. To reduce cost and copper usage, switching happens on a high frequency of 300kHz. This increases the switching losses but greatly reduces the inductor size and cost compared to switching supplies running on lower frequencies. Additional filter circuits like snubbers are necessary to keep the control signals and therefore the output current stable.
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De bestuurlijke informatievoorziening voor het tactische en strategische management kan tegenwoordig tot stand komen op basis geavanceerde Executive Information Systems (EIS). Maar 'bestuurlijke informatievoorziening met EIS' vraagt om essentiele basiskennis omtrent besturen en bestuurlijke informatie binnen organisaties. In dit artikel staan met name de toepassing van de tools centraal.
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Abstract Objectives The aim of this review is to establish the effectiveness of psychological relapse prevention interventions, as stand-alone interventions and in combination with maintenance antidepressant treatment (M-ADM) or antidepressant medication (ADM) discontinuation for patients with remitted anxiety disorders or major depressive disorders (MDD). Methods A systematic review and a meta-analysis were conducted. A literature search was conducted in PubMed, PsycINFO and Embase for randomised controlled trials (RCTs) comparing psychological relapse prevention interventions to treatment as usual (TAU), with the proportion of relapse/recurrence and/or time to relapse/recurrence as outcome measure. Results Thirty-six RCTs were included. During a 24-month period, psychological interventions significantly reduced risk of relapse/recurrence for patients with remitted MDD (RR 0.76, 95% CI: 0.68–0.86, p<0.001). This effect persisted with longer follow-up periods, although these results were less robust. Also, psychological interventions combined with M-ADM significantly reduced relapse during a 24-month period (RR 0.76, 95% CI: 0.62–0.94, p = 0.010), but this effect was not significant for longer follow-up periods. No meta-analysis could be performed on relapse prevention in anxiety disorders, as only two studies focused on relapse prevention in anxiety disorders. Conclusions In patients with remitted MDD, psychological relapse prevention interventions substantially reduce risk of relapse/recurrence. It is recommended to offer these interventions to remitted MDD patients. Studies on anxiety disorders are needed.
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Lectoraten doen onderzoek naar de kracht van diversiteit. Inholland wil inzetten op de kracht van diversiteit. Dat is actueel en urgent, maar weten we wel voldoende over hóe we dat als hogeschool kunnen doen? Bijvoorbeeld: Hoe kunnen we studenten zo leren omgaan met diversiteit dat zij toegerust worden om diversiteit (in al zijn vormen) als kracht in te zetten tijdens hun opleiding en stage, en later in hun loopbaan. En: Welke kwaliteiten hebben docenten daarvoor nodig en welke eisen stelt dat aan de leeromgeving (binnen de hogeschool en op stageplekken)? Vijf lectoraten van Hogeschool Inholland hebben samengewerkt om antwoord te geven op dergelijke vragen. Het gaat daarbij om de lectoraten Dynamiek van de Stad; Jeugd en Samenleving; Diversiteitsvraagstukken; Media, Cultuur & Burgerschap en Pedagogisch-didactisch Handelen. Het onderzoek richtte zich op studenten en docenten van Hogeschool Inholland en op professionals in het beroepenveld die stageplekken aanbieden aan de studenten van verschillende opleidingen. Het onderzoek is uitgevoerd in Amsterdam, Diemen en Rotterdam, bij vier verschillende opleidingen: Social Work, Pedagogiek, Business Studies en Communicatie. Deze en ook andere opleidingen kunnen met de resultaten en aanbevelingen aan de slag. Binnenkort komt er ook een factsheet en wordt het rapport besproken in de Community of Practice Diversitiet van Hogeschool Inholland.
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This chapter will focus on the deep evolutionary history of the cognitive capacities underlying linguistic iconicity. The complex capacity for linguistic iconicity has roots in a more general cross-modal ability present throughout the animal kingdom, cross-modal transfer. Cross-modal transfer is the ability to make basic inferences about sensory properties of an object in multiple modalities based on experience from only one. This situates iconicity as a fundamentally cross-modal phenomenon; part of a broader, uniquely human cross-modal cognitive suite which includes relatively rare phenomena like synesthesia, alongside more ubiquitous phenomena like sensory metaphor and cross-modal correspondences. Evidence suggests the evolutionarily deep capacity for cross-modal transfer was honed into more sophisticated capacities underlying iconicity by an evolutionary ratchet of increased prosociality during human self-domestication. This period provided strong selective pressures for increasingly complex cross-sensory communication, and eventually, the predominantly arbitrary symbolic systems that underpin modern human language. This is a peer-reviewed preprint of the work below.Cuskley, Christine and Kees Sommer (forthcoming). The evolution of linguistic iconicity and the cross-modal cognitive suite. To appear in Olga Fisher, Kimi Akita, and Pamela Perniss (eds.), Oxford Handbook of Iconicity in Language. Oxford University Press: Oxford, UK.
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Teacher beliefs have been shown to play a major role in shaping educational practice, especially in the area of grammar teaching―an area of language education that teachers have particularly strong views on. Traditional grammar education is regularly criticized for its focus on rules-of-thumb rather than on insights from modern linguistics, and for its focus on lower order thinking. A growing body of literature on grammar teaching promotes the opposite, arguing for more linguistic conceptual knowledge and reflective or higher order thinking in grammar pedagogy. In the Netherlands, this discussion plays an important role in the national development of a new curriculum. This study explores current Dutch teachers’ beliefs on the use of modern linguistic concepts and reflective judgment in grammar teaching. To this end, we conducted a questionnaire among 110 Dutch language teachers from secondary education and analyzed contemporary school textbooks likely to reflect existing teachers’ beliefs. Results indicate that teachers generally appear to favor stimulating reflective judgement in grammar teaching, although implementing activities aimed at fostering reflective thinking seems to be difficult for two reasons: (1) existing textbooks fail to implement sufficient concepts from modern linguistics, nor do they stimulate reflective thinking; (2) teachers lack sufficient conceptual knowledge from linguistics necessary to adequately address reflective thinking.
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The 6th International Human Rights Education Conference is about teaching human rights. The purpose of this convention is to protect and promote the right of people with disabilities to participate equally in societal life. Implementation of the convention is a responsibility of the national government. At the Utrecht University of Applied Sciences a social work course now includes an introductory lecture on human rights using objects and a game that addresses the UN Convention on the Rights of Persons with Disabilities.
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