Rationale: Diagnosis of sarcopenia in older adults is essential for early treatment in clinical practice. Bio-electrical impedanceanalysis (BIA) may be a valid means to assess appendicular lean mass (ALM) in older adults, but limited evidence is available.Therefore, we aim to evaluate the validity of BIA to assess ALM in older adults.Methods: In 215 community dwelling older adults (age ≥ 55 years), ALM was measured by BIA (Tanita MC-780; 8-points) andcompared with dual-energy X-ray absorptiometry (DXA, Hologic Discovery A) as reference. Validity for assessing absolute values ofALM was evaluated by: 1) bias (mean difference), 2) percentage of accurate predictions (within 5% of DXA values), 3) individualerror (root mean squared error (RMSE), mean absolute deviation), 4) limits of agreement (Bland-Altman analysis). For diagnosis oflow ALM, the lowest quintile of ALM by DXA was used (below 21.4 kg for males and 15.4 for females). Sensitivity and specificityof detecting low ALM by BIA were assessed.Results: Mean age of the subjects was 71.9 ± 6.4, with a BMI of 25.8 ± 4.2 kg/m2, and 70% were females. BIA slightlyunderestimated ALM compared to DXA with a mean bias of -0.6 ± 0.2 kg. The percentage accurate predictions was 54% withRMSE 1.6 kg and limits of agreements -3.0 – +1.8 kg. Sensitivity was 79%, indicating that 79% of subjects with low ALMaccording to DXA also had low ALM with the BIA. Specificity was 90%, indicating that 90% of subjects with ‘no low’ ALMaccording to DXA also had ‘no low’ ALM with the BIA.Conclusions: This comparison showed a poor validity of BIA to assess absolute values of ALM, but a reasonable sensitivity andspecificity to diagnose a low level of ALM in community-dwelling older adults in clinical practice.
Rationale: The number of obese older adults with diabetes type 2 is increasing worldwide. Weight loss treatment in this group seems beneficial for cardio-metabolic and other health outcomes, but it might reduce muscle mass and bone mineral density (BMD). The association between obesity and BMD is controversial, and the role of muscle mass and dietary protein intake is not fully clear. This study explores the association between body weight, muscle mass, dietary protein intake, and physical activity level on BMD in obese older adults with diabetes type 2. Methods: For this cross-sectional analysis we used baseline data of a 13-week randomized trial evaluating the effect of a multi-modal intervention on muscle preservation and insulin sensitivity during a weight loss program in obese older adults (55-80y) with diabetes type 2 (PROBE). Body weight was measured using a calibrated scale (Life Measurement), appendicular lean mass (ALM) was used as a proxy for muscle mass and was measured by dual-energy X-ray absorptiometry (DXA, Hologic Discovery A), dietary protein intake was estimated by a 3-day food record, Physical Activity Level (PAL) was estimated by a 3-day activity record, and hip BMD was assessed by DXA. After determination of Pearson’s correlation coefficients for body weight, ALM, protein intake, and PAL with BMD, linear regression analysis was performed with significantly correlating determinants (body weight [kg], ALM [kg], protein intake [g/kg/d], and/or PAL [-]) and hip BMD (g/cm2) as outcome variable. Results: Mean age of the 122 included subjects was 67±6y, with a BMI of 33±4kg/m2. 65% of subjects were male. Body weight and ALM correlated significantly with BMD (r=0.34, p<0.001; r=0.43, p<0.001) whereas protein intake and PAL did not (r=0.02, p=0.84; r=0.005, p=0.95). Linear regression analysis with the two determinants body weight and ALM identified ALM as being significantly associated with BMD, whereas body weight was not. Beta for ALM was +0.011 g/cm2 (95% CI: 0.004 – 0.017; p<0.01), meaning that a 1 kg increase in ALM is associated with a +0.011 g/cm2 increase in BMD. Conclusion: In this explorative cross-sectional analysis appendicular muscle mass is positively associated with BMD, rather than body weight, protein intake, and physical activity level.
In dit KIEM-project verkennen we de haalbaarheid van een nieuw concept voor energietransitie en circulaire economie: EnTranCe-for-a-Community. Dit is een generiek concept voor draagvlak voor lokale waarde-creatie en groene energieproductie. Na discussies met ons werkveld implementeren we EnTranCe-for-a-Community hier als een publiekskas met technologie om lokale biomassa om te zetten in groene energie (gas) en biocompost. We onderzoeken of dit concept een aantrekkelijke uitbreiding is voor lokale energie-initiatieven en energiecoöperaties (doorgaans bezig met zon en/of wind) als alternatief voor aardgas of een warmtenet. We willen weten of en hoe het realiseren van een EnTranCe-for-a-Community-project op een concrete locatie kansrijk is. Dat kansrijk zijn wordt op drie niveaus onderzocht: (a) de bijdrage aan de lokale energietransitie (kosten/baten); (b) de bijdrage aan een lokale circulaire economie door verwaarding van lokale biomassa (kosten/baten) en (c) de bijdrage aan draagvlak en enthousiasme (en dus praktische haalbaarheid) voor deze ontwikkelingen, door het nauw betrekken van lokale stakeholders bij de studie en eventuele implementatie. EnTranCe-for-a-Community combineert eerder opgedane kennis en kunde op een innovatieve manier en beoogt lokale energietransitie te verbreden naar lokale biomassa. Deze haalbaarheidsstudie wordt uitgevoerd door een nieuw samenwerkingsverband van partners uit de coöperatieve en lokale energiesector, MKB en het expertisecentrum EnTranCe van de Hanzehogeschool Groningen. Allen dragen bij aan de haalbaarheidsstudie met kennis, kunde en netwerken die nodig zijn voor dit onderzoek en voor realisatie op langere termijn, indien voldoende kansrijk. We gebruiken de beproefde iteratieve Lean Startup-aanpak, die juist is ontwikkeld voor dit type complexe en multidimensionale projecten. We gaan komen tot een business en een mission model voor eventuele toekomstige implementatie ergens in Groningen op basis van de gedocumenteerde kansrijkheid van het concept. Op die manier zal dit KIEM-project de basis leggen voor een veel groter projectvoorstel voor verdere realisatie.
The objective of Sustainable Solid Biofuel project is to contribute to a zero-waste and low-carbon emission production of charcoal by evaluating the feasibility and energy efficiency of three different conversion technologies. According to the IEA’s World Energy Outlook 2015 3 billion (more than a third of the global population) use solid biomass as wood, charcoal, or animal waste for cooking and heating1. Charcoal is one of the most widely used of the solid biofuels. In current charcoal production processes the gas stream from pyrolysis are mostly directly released to the environment which wastes energy and causes serious environmental pollution. However, the production of charcoal can be improved to be practiced on a sustainable basis by careful selection of wood or alternative biomass source as wood waste or agricultural residues and further focusing on harvesting strategy and production techniques. In the conversion process it is necessary to increase the energy efficiency while reducing emissions. Further sustainability can be increased by processing the smoke that is exhausted from the kiln, that correspond to roughly one third of the whole biomass. Within the volatile components in the smoke there are chemicals which can be used, for example, as industrial cleaners or wood preservatives and thus one of the environmental drawbacks of charcoal production can be eliminated and turned into another product input. Brazil is the world's largest charcoal producer2 consequently the state of the art of the recearch in this field can be found in Brazil. In this Sustainable Solid Biofuels project one of the leading universities of Brazil, the Universidade Federal de Viçosa (UFV) is joining forces with Avans University of Applied Sciences and two Dutch SMEs Privium B.V. and Charcotec B.V. to carry out the evaluation of the improvements that can be achieved in the energy efficiency.
