Background Having a partner is associated with better prognosis in patients with cardiovascular disease. However, the influence of partners on modification of patients’ lifestyle-related risk factors (LRFs) is unclear. Therefore, we studied the influence of partners and the level of partner participation on LRF modification in patients after an acute coronary syndrome (ACS) or revascularization. Methods The RESPONSE-2 trial was a community-based lifestyle intervention trial comparing nurse-coordinated referral to a comprehensive set of lifestyle interventions (physical activity, weight reduction and/or smoking cessation) to usual care. In the current analysis, we investigated the association of having a partner on the improvement in >1 LRF without deterioration in other LRFs at 12 months follow-up. Secondary, the influence of the level of partner participation (participating partner, non-participating partner and no partner) in the intervention group was studied. Results In total 824 individuals (411 intervention, 413 control) were included in the analysis. The presence of a partner was comparable in both groups (intervention 74%, control 69%). In the intervention group, 48% of partners participated in the lifestyle interventions. Overall, having a partner was positively associated with improvement in LRFs (odds ratio (OR) 2.57 (95% confidence interval (CI) 1.57 – 4.21), p<0.001). In the intervention group, having a participating partner was also positively associated with improvement in LRFs compared to patients without a partner (OR 2.45 95% CI 1.25 – 4.79, p=0.009). When analysed the influence of partners on LRFs separately, patients with a participating partner were most successful in reducing weight compared to patients without a partner (OR 2.71 95% CI 1.16 – 6.36, p=0.02). Conclusion Having a partner is associated with improvement on LRFs in patients after ACS or revascularization. Moreover, patients with participating partners in the lifestyle programs were most successful in LRF modification. Involvement of partners in lifestyle interventions should be considered in routine practice.
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The purpose of this research is to discover what interdependencies can be identified between business model elements. After a literature analysis, two case studies in the media industry are presented. From the literature analysis a new categorization in three types of business models is identified: calculative, descriptive and dynamic models. The results of the case studies suggest that in particular the key partners provide an important contribution to the value proposition, in the sense that they co-create the media concept. Based on these results a first sketch of a new business model frame workis proposed.
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Het SaP-initiatief (Student as Partners) bij Inholland beoogt de relatie tussen studenten en docenten te versterken door partnerschap te stimuleren in het onderwijsproces. Dit houdt in dat studenten actief betrokken worden bij curriculumontwikkeling en andere onderwijs gerelateerde besluitvorming. Dit project heeft een methode en diverse instrumenten ontwikkeld, zoals de SaP-radar, om de dialoog te bevorderen en verbeteringen in het onderwijs aan te moedigen. Door middel van workshops zijn waardevolle inzichten verkregen, zoals het belang van gelijkwaardigheid, flexibiliteit, en open dialoog tussen studenten en docenten. De SaP-radar methode heeft ook onverwachte aspecten blootgelegd, zoals de discrepantie tussen verbale en non-verbale communicatie en de uitdagingen rond machtsbalans en afhankelijkheid. Het project benadrukt de noodzaak van continue evaluatie, feedback, en training om effectief partnerschap te bereiken.
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Background: Marital status is associated with prognosis in patients with cardiovascular disease (CVD). However, the influence of partners on successful modification of lifestyle-related risk factors (LRFs) in secondary CVD prevention is unclear. Therefore, we studied the association between the presence of a partner, partner participation in lifestyle interventions and LRF modification in patients with coronary artery disease (CAD). Methods: In a secondary analysis of the RESPONSE-2 trial (n = 711), which compared nurse-coordinated referral to community-based lifestyle programs (smoking cessation, weight reduction and/or physical activity) to usual care in patients with CAD, we investigated the association between the presence of a partner and the level of partner participation on improvement in >1 LRF (urinary cotinine <200 ng/l, ≥5% weight reduction, ≥10% increased 6-min walking distance) without deterioration in other LRFs at 12 months follow-up. Results: The proportion of patients with a partner was 80% (571/711); 19% women (108/571). In the intervention group, 48% (141/293) had a participating partner in ≥1 lifestyle program. Overall, the presence of a partner was associated with patients' successful LRF modification (adjusted risk ratio (aRR) 1.93, 95% confidence interval (CI) 1.40-2.51). A participating partner was associated with successful weight reduction (aRR 1.73, 95% CI 1.15-2.35). Conclusion: The presence of a partner is associated with LRF improvement in patients with CAD. Moreover, patients with partners participating in lifestyle programs are more successful in reducing weight. Involving partners of CAD patients in weight reduction interventions should be considered in routine practice.
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Onze sport- en beweegsamenleving is fundamenteel aan het veranderen. Schoolgaande kinderen bewegen steeds minder. De gevolgen van bewegingsarmoede zijn merkbaar. Per generatie nemen de motorische vaardigheden af en neemt het overgewicht toe. In dit artikel een pleidooi voor samenwerking met partners vanuit verschillende perspectieven: boundary crossing.
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Binnen de begrippen Student Engagement, studentparticipatie en Students as Partners (SAP) komt de betrokkenheid van studenten aan bod. Met deze infosheet leggen we deze begrippen en de verschillen ertussen beknopt uit.
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Purpose:To determine which health care provider and what timing is considered most suitable to discuss sexual and relationalchanges after prostate cancer treatment according to the point of view of men and their partners. Methods A cross-sectional survey was conducted among men diagnosed with prostate cancer or treated after active surveillance, who received laparoscopic radical prostatectomy, brachytherapy, intensity-modulated radiotherapy, and/or hormonal therapy. If applicable, partners were included as well. Results In this survey, 253 men and 174 partners participated. Mean age of participating men was 69.3 years (SD 6.9, range 45–89). The majority (77.8%) was married and average length of relationship was 40.3 years (SD 14.1, range 2–64). Out of 250 men, 80.5% suffered from moderate to severe erectile dysfunction. Half of them(50.2%, n = 101) was treated for erectile dysfunction and great part was partially (30.7%, n = 31) up to not satisfied (25.7%, n = 26). Half of the partners (50.6%, n = 81) found it difficult to cope with sexual changes. A standard consultation with a urologist-sexologist to discuss altered sexuality is considered preferable by 74.7% (n = 183). Three months after treatment was the most suitable timing according to 47.6% (n = 49). Conclusions During follow-up consultations, little attention is paid to the impact of treatment-induced sexual dysfunction on the relationship of men with prostate cancer and their partners. A standard consultation with a urologistsexologist 3 months after treatment to discuss sexual and relational issues is considered as most preferable.
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Pesten op school is een beladen onderwerp dat de relatie tussen leerkracht en ouders flink op de proef stelt. Een gesprek over pesten ligt gevoelig omdat het raakt aan de opvoeding thuis. Bovendien zien leerkrachten en ouders een kind vanuit een verschillend perspectief en proberen zij vanuit verschillende invloedssferen het pesten te beteugelen. Er zijn de afgelopen jaren verschillende maatregelen genomen om het pesten op basisscholen tegen te gaan. Voor basisscholen zijn er verschillende sociale veiligheidsprogramma’s ontwikkeld. Daarnaast bestaat er een breed scala aan werkwijzen, trainingen en tools om leerkrachten te helpen in de samenwerking met ouders om de schoolse ontwikkeling van hun kind te versterken. In de meeste programma's voor sociale veiligheid ontbreekt het echter aan handvatten voor de leerkracht om met ouders samen te werken als er daadwerkelijk sprake is van een pestsituatie. Dit onderzoek heeft laten zien dat een doeltreffende aanpak voor de samenwerking tussen leerkrachten en ouders rond pesten niet kan bestaan uit een enkel instrument of protocol, maar een samenhangend geheel moet vormen van gedeelde definities, heldere communicatie, een vertrouwensband en constante afstemming. Literatuurstudie heeft laten zien dat samenwerking een cyclisch proces is dat beïnvloed wordt door persoonlijke, interpersoonlijke, organisatorische en maatschappelijke factoren. Een sociale netwerkstudie liet zien dat ouders over het algemeen redelijk goed zicht hebben op de positieve relaties en vriendschappen van hun kind, maar dat ze een minder scherp beeld hebben van subtiele of negatieve interacties. De kwalitatieve studie maakte duidelijk welke knelpunten en succesfactoren ouders, leerkrachten en kinderen ervaren, en onderstreept het belang van context, nuance en relationele aspecten.In een ontwerpstudie is op basis van deze inzichten, in co-creatie met ouders en leerkrachten, een strategie ontwikkeld die resulteerde in een handreiking. Deze handreiking biedt scholen en leerkrachten praktische handvatten om doelgerichter en met meer vertrouwen met ouders samen te werken rond pesten. Voor het vervolg zou het waardevol zijn bewijs te zoeken (evidence based) dat deze aanpak voor de samenwerking met ouders rond pesten effectief is.
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Objective To evaluate the effects of a psycho-educational intervention on caregiver burden in partners of patients with postoperative heart failure. Background Since partners of cardiac surgery patients play a significant role in the patient’s recovery, it is important to address their needs during hospitalization and after discharge. Methods Forty-two patients with postoperative heart failure and their partners participated in a randomized controlled pilot study. Dyads in the intervention group received psycho-educational support from a multidisciplinary team. Dyads in the control group received usual care. Results No significant differences were found in the performance of caregiving tasks and perceived caregiver burden in the control versus the intervention group. Conclusion A pilot study exploring the effects of a psycho-educational intervention in patients and their partners did not reveal significant effects with regard to reduced feelings of burden in partners. Alleviating caregiver burden in partners may need a more intense or specific approach.
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Clinical outcomes in ROS1-fusion positive (ROS1+) non-small cell lung cancer (NSCLC) by fusion partner and resistance mechanisms are limited. This cohort study included 56 ROS1+ patients (FISH or NGS confirmed); fusion partners were identified in 27 cases, including CD74 (n = 10), EZR (n = 7), and SDC4 (n = 7). Clinical data were available for 50 patients (median age 62; 51% female; 32% never-smokers). Forty patients received tyrosine kinase inhibitors (TKIs), mostly crizotinib (n = 38). Crizotinib showed a 55% objective response rate (ORR) and a median progression-free survival (mPFS) of 5.3 months. Brain metastases (HR 2.65, 95% CI 1.06–6.60, P = 0.037) and prior chemotherapy (HR 3.17, 95% CI 1.35–7.45, P = 0.008) had a higher risk of progression. Sixteen patients received subsequent lorlatinib, with an ORR of 28% and mPFS of 3.7 months. G2032R and L2026M resistance mutations were identified in four lorlatinib non-responders, and in vitro studies confirmed resistance to lorlatinib. Fusion partners did not affect crizotinib outcomes. Lorlatinib was ineffective against on-target resistance. Real-world data showed lower TKI efficacy than clinical trials, highlighting the role of clinical and molecular factors in treatment response.
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