OBJECTIVE: Osteopenia is a common complication of juvenile idiopathic arthritis (JIA). In adults, low bone density and increased fracture risk are associated with low vitamin K status of bone. The vitamin K-dependent protein osteocalcin plays an important role in bone metabolism. Its activity depends upon post-translational carboxylation in which vitamin K is an essential co-factor. Hence, vitamin K deficiency leads to under-carboxylated (i.e., inactive) osteocalcin (ucOC). Little is known about the vitamin K status and bone health in children with juvenile idiopathic arthritis (JIA). We studied the vitamin K status of bone and its association with bone mass properties in children with JIA compared to healthy children.METHODS: We performed a cross sectional study in 55 children with JIA and 54 healthy controls between 6-18 years of age. Bone markers, ultrasound bone mass properties and vitamin K status of bone were determined.RESULTS: Overall, no differences in vitamin K status of bone were found between the study groups. Among children with JIA, a high ratio of ucOC/cOC indicating low vitamin K status was associated with low bone ultrasound parameters, whereas children with a high vitamin K status had markedly higher bone properties. This association was independent of physical activity, age, gender and BMI.CONCLUSION: These results suggest that vitamin K may be one of multiple risk factors for low bone mass in children with JIA, in addition to other recognized determinants of bone mass. The question remains whether JIA patients would benefit from increased dietary vitamin K intake.
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Rationale: The number of obese older adults with diabetes type 2 is increasing worldwide. Weight loss treatment in this group seems beneficial for cardio-metabolic and other health outcomes, but it might reduce muscle mass and bone mineral density (BMD). The association between obesity and BMD is controversial, and the role of muscle mass and dietary protein intake is not fully clear. This study explores the association between body weight, muscle mass, dietary protein intake, and physical activity level on BMD in obese older adults with diabetes type 2. Methods: For this cross-sectional analysis we used baseline data of a 13-week randomized trial evaluating the effect of a multi-modal intervention on muscle preservation and insulin sensitivity during a weight loss program in obese older adults (55-80y) with diabetes type 2 (PROBE). Body weight was measured using a calibrated scale (Life Measurement), appendicular lean mass (ALM) was used as a proxy for muscle mass and was measured by dual-energy X-ray absorptiometry (DXA, Hologic Discovery A), dietary protein intake was estimated by a 3-day food record, Physical Activity Level (PAL) was estimated by a 3-day activity record, and hip BMD was assessed by DXA. After determination of Pearson’s correlation coefficients for body weight, ALM, protein intake, and PAL with BMD, linear regression analysis was performed with significantly correlating determinants (body weight [kg], ALM [kg], protein intake [g/kg/d], and/or PAL [-]) and hip BMD (g/cm2) as outcome variable. Results: Mean age of the 122 included subjects was 67±6y, with a BMI of 33±4kg/m2. 65% of subjects were male. Body weight and ALM correlated significantly with BMD (r=0.34, p<0.001; r=0.43, p<0.001) whereas protein intake and PAL did not (r=0.02, p=0.84; r=0.005, p=0.95). Linear regression analysis with the two determinants body weight and ALM identified ALM as being significantly associated with BMD, whereas body weight was not. Beta for ALM was +0.011 g/cm2 (95% CI: 0.004 – 0.017; p<0.01), meaning that a 1 kg increase in ALM is associated with a +0.011 g/cm2 increase in BMD. Conclusion: In this explorative cross-sectional analysis appendicular muscle mass is positively associated with BMD, rather than body weight, protein intake, and physical activity level.
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Identifying factors that predict health-related quality of life (QOL) following hematopoietic SCT, is important in estimating patients’ abilities to adjust to the consequences of their disease and treatment. As the studies that have been published on this subject are scattered, the present study aimed to systematically review prognostic factors for health-related QOL after auto- and allo-SCT in hematological malignancies. A systematic, computerized search in Medline, EMBASE, PsycINFO and the Cochrane Library was conducted from 2002 to June 2010. The methodological quality of the studies was assessed using an adaptation of Hayden's criteria list. Qualitative data synthesis was performed to determine the strength of the scientific evidence. In all, 35 studies fulfilled the selection criteria. Strong–moderate evidence was found for GVHD, conditioning regimen, being female, younger age, receiving less social support and pre-transplant psychological distress as predictors of various aspects of health-related QOL following hematopoietic SCT. The results of this review may help transplant teams in selecting patients at risk for experiencing a diminished health-related QOL following hematopoietic SCT. Follow-up treatment can be provided in order to promote QOL.
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Lichamelijke activiteiten waarbij het skelet wordt belast, zoals wandelen of hardlopen, hebben een positief effect op de botgezondheid. Activiteiten waarbij niet of nauwelijks belasting van het skelet plaatsvindt, zoals fietsen of zwemmen, worden vaker in verband gebracht met een verminderde botgezondheid. Dit is met name een probleem voor (prof-)wielrenners, waarbij lange dagen op de fiets worden doorgebracht. Alarmerend is het feit dat de meerderheid van de profwielrenners te maken heeft met broze botten (osteopenie of osteoporose). Broze botten verhogen het risico op botbreuken. Dat is niet alleen zorgwekkend tijdens de actieve wielercarrière, maar vooral ook daarna. Een lage botdichtheid op jonge leeftijd verhoogt de kans op osteoporose en botbreuken in het latere leven. De vraag vanuit de beroepspraktijk is hoe de botgezondheid van (jonge) wielrenners verbeterd kan worden. Ondanks dat verschillende bewegings- en voedingsinterventies effectief zijn bevonden bij ouderen, is het niet bekend of zulke interventies ook effectief kunnen zijn voor (jonge) wielrenners. Bovendien moet een interventie inpasbaar zijn in het dagelijkse leven van (prof-)wielrenners en niet interfereren met de reguliere trainingsarbeid. Een veelbelovende strategie die aan deze eisen voldoet zijn korte dagelijkse springsessies gecombineerd met collageensuppletie. In dit innovatief pilotonderzoek zullen we testen of deze strategie daadwerkelijk een positief effect heeft op het botmetabolisme. Vervolgens kan de strategie geïmplementeerd worden binnen het profwielrennen, waarbij ook de botgezondheid op langere termijn onderzocht kan worden. Het project wordt uitgevoerd door de Hogeschool van Arnhem en Nijmegen, in samenwerking met wierlerteams Jumbo-Visma en Parkhotel Valkenburg (profploegen), KNWU (wielerunie), Niche4Health (collageensupplementen), en Universiteit Maastricht (wetenschappelijke input en bloedanalyse).
Along with the rapidly growing number of disabled people participating in competitive sports, there is an increased need for (para)medical support in disability sports. Disabled athletes experience differences in body composition, metabolism, training load and habitual activity patterns compared with non-disabled athletes. Moreover, it has been suggested that the well-recognized athlete triad, and low energy availability and low bone mineral density in particular, is even a greater challenge in disabled athletes. Therefore, it is not surprising that sport nutritionists of disabled athletes have expressed an urgency for increased knowledge and insights on the nutritional demands of this group. This project aims to investigate energy expenditure, dietary intake, body composition and bone health of disabled athletes, ultimately leading to nutritional guidelines that promote health and optimal sports performance for this unique population. For this purpose, we will conduct a series of studies and implementation activities that are inter-related and build on the latest insights from sports practice, technology and science. Our international consortium is highly qualified to achieve this goal. It consists of knowledge institutes including world-leading experts in sport and nutrition research, complemented with practical insights from nutritionists working with disabled athletes and the involvement of athletes and teams through the Dutch and Norwegian Olympic committees. The international collaboration, which is a clear strength of this project, is not only focused on research, but also on the optimization of professional practice and educational activities. In this regard, the outcomes of this project will be directly available for practical use by the (para)medical staff working with disabled athletes, and will be extensively communicated to sport teams to ensure that the new insights are directly embedded into daily practice. The project outcomes will also be incorporated in educational activities for dietetics and sport and exercise students, thereby increasing knowledge of future practitioners.
Pectcof B.V heeft een bio-raffinagetechnologie ontwikkeld waardoor koffiepulp, de reststroom die vrijkomt nadat de pitten (koffiebonen) onder mechanische druk uit de koffiebes zijn geperst, gebruikt kan worden. Het doel van het huidige Pectcof-raffinageproces is het isoleren van Dutch Gum, een emulgator die bestaat uit eiwitten en pectine. Bij winning van dit product ontstaan twee zijstromen: een vaste, onoplosbare stroom en een waterige stroom. Het plan is deze zijstromen volledig te benutten. Allereerst wordt de aandacht gericht op de isolatie en identificatie van de hoogwaardige polyfenolen daaruit. Healthy People B.V. is producent van onder andere vruchtensappen met natuurlijke antioxidanten, vitaminen en suikers. Samen met Pectcof willen zij de potentie van polyfenolen onderzoeken, waarbij onder andere het valoriseren van de antioxidanten van belang is. Pectcof en Healthy People bundelen hun krachten hiervoor met Avans Center of Expertise Biobased Economy (CoE BBE) en HAS Hogeschool. De Biobased Products groep, onder leiding van Dr. Dorien Derksen, heeft de expertise in natuurlijke inhoudsstoffen en antioxidanten die noodzakelijk is voor het onderzoek naar de polyfenolen om de MKB-bedrijven te helpen om de waardevolle inhoudsstoffen in de raffinagezijstromen en de toepassingsmogelijkheden verder te definiëren. HAS Hogeschool levert specifieke expertise op het gebied van voedselgericht sensorische testen. Het doel van het OxiCof project is om de antioxidanten in de waterige zijstroom van het huidige Pectcof-raffinageproces te identificeren en kwantificeren voor verder onderzoek en valorisatie. Tevens worden de sensorische eigenschappen van een selectie van producten getest. Op basis van de resultaten kan de valorisatie van deze antioxidanten goed onderbouwd worden.