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Development of sucking patterns in preterm infants

The studies reported on in this thesis addressed the development of suckingpatterns in preterm newborns. Preterm infants often have problems learningto suckle at the breast or to drink from a bottle. It is unclear whether this isdue to their preterm birth or whether it is the consequence of neurologicaldamage. From the literature, as well as from daily practice, we know thatthere is much variation in the time and in the way children start suckingnormally. Factors such as birth weight and gestational age may indeed berisk factors but they do not explain the differences in development. A smallspot-check proved that most hospitals in the Netherlands start infants onoral feeding by 34 weeks’ post-menstrual age (pma). By and large the policyis aimed at getting the infant to rely on oral feeding entirely as soon aspossible. The underlying rationale is to reduce the stay in hospital, and theidea that prolonged tube-feeding delays or even hampers the development ofsucking.

The impact of bed rest on human skeletal muscle metabolism

Insulin sensitivity and metabolic flexibility decrease in response to bed rest, but the temporal and causal adaptations in human skeletal muscle metabolism are not fully defined. Here, we use an integrative approach to assess human skeletal muscle metabolism during bed rest and provide a multi-system analysis of how skeletal muscle and the circulatory system adapt to short- and long-term bed rest (German Clinical Trials: DRKS00015677). We uncover that intracellular glycogen accumulation after short-term bed rest accompanies a rapid reduction in systemic insulin sensitivity and less GLUT4 localization at the muscle cell membrane, preventing further intracellular glycogen deposition after long-term bed rest. We provide evidence of a temporal link between the accumulation of intracellular triglycerides, lipotoxic ceramides, and sphingomyelins and an altered skeletal muscle mitochondrial structure and function after long-term bed rest. An intracellular nutrient overload therefore represents a crucial determinant for rapid skeletal muscle insulin insensitivity and mitochondrial alterations after prolonged bed rest.

Modelling Complex Relationships Between Sustainable Competitiveness and Digitalization

Digitalization is the core component of future development in the 4.0 industrial era. It represents a powerful mechanism for enhancing the sustainable competitiveness of economies worldwide. Diverse triggering effects shape future digitalization trends. Thus, the main research goal in this study is to use sustainable competitiveness pillars (such as social, economic, environmental and energy) to evaluate international digitalization development. The proposed empirical model generates comprehensive knowledge of the sustainable competitiveness-digitalization nexus. For that purpose, a nonlinear regression has been applied on gathered annual data that consist of 33 European countries, ranging from 2010 to 2016. The dataset has been deployed using Bernoulli’s binominal distribution to derive training and testing samples and the entire analysis has been adjusted in that context. The empirical findings of artificial neural networks (ANN) suggest strong effects of the economic and energy use indicators on the digitalization progress. Nonlinear regression and ANN model summary report valuable results with a high degree of coefficient of determination (R2>0.9 for all models). Research findings state that the digitalization process is multidimensional and cannot be evaluated as an isolated phenomenon without incorporating other relevant factors that emerge in the environment. Indicators report the consumption of electrical energy in industry and households and GDP per capita to achieve the strongest effect.

Application of a dynamic energy budget model to Mytilus edulis (L.)

SaxShirt

In the SaxShirt project Saxion is working on smart textile solution, but Saxion is not the only organization; commercial products are popping up in the market everywhere. This paper gives an up-to-date overview of the commercially available products, to have a clear view on the current market, to learn from the existing solutions and be able to position the SaxShirt with respect to the existing developments.

Digitale schermen in de etalage