Background: G-protein coupled receptors (GPCRs) are involved in many different physiological processes and their function can be modulated by small molecules which bind in the transmembrane (TM) domain. Because of their structural and sequence conservation, the TM domains are often used in bioinformatics approaches to first create a multiple sequence alignment (MSA) and subsequently identify ligand binding positions. So far methods have been developed to predict the common ligand binding residue positions for class A GPCRs.Results: Here we present 1) ss-TEA, a method to identify specific ligand binding residue positions for any receptor, predicated on high quality sequence information. 2) The largest MSA of class A non olfactory GPCRs in the public domain consisting of 13324 sequences covering most of the species homologues of the human set of GPCRs. A set of ligand binding residue positions extracted from literature of 10 different receptors shows that our method has the best ligand binding residue prediction for 9 of these 10 receptors compared to another state-of-the-art method.Conclusions: The combination of the large multi species alignment and the newly introduced residue selection method ss-TEA can be used to rapidly identify subfamily specific ligand binding residues. This approach can aid the design of site directed mutagenesis experiments, explain receptor function and improve modelling. The method is also available online via GPCRDB at http://www.gpcr.org/7tm/. © 2011 Sanders et al; licensee BioMed Central Ltd.
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Strengthening sustainability in global supply chains requires producers, buyers, and nonprofit organizations to collaborate in transformative cross-sector partnerships (CSPs). However, the role played by nature in such partnerships has been left largely unattended in literature on CSPs. This article shows how strategizing nature helps CSPs reach their transformative potential. Strategizing nature entails the progressive revealing and reconciling of temporal tensions between “plants, profits, and people.” We show how a CSP took a parallel approach—recognizing the divergent temporalities of plants, people, and profits as interlaced and mutually determined—toward realizing their objective of implementing living wages in a sub-Saharan African country’s the tea industry, simultaneously driven by the revitalization of tea plantations. The promise of better quality tea leaves allowed partners to take a “leap of faith” and to tackle pressing issues before the market would follow. Our findings thus show the potential of CSPs in driving regenerative organizing.
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Using a case study of the tea producer Eastern Produce Malawi, this research investigates which factors which influence companies upstream in the global supply chains to adopt a corporate social responsibility (CSR) agenda. Although external pressures, such as demands from Western consumers or international organizations and their related initiatives, may have shaped Eastern Produce Malawi's CSR agenda, strong internal organizational contingencies, including transformational leaders who recognize the significance of ethical issues and strong organizational values, led it to adopt this CSR agenda in practice. This study underscores the significance of using an integrative framework to explain various CSR drivers for companies. It concludes with managerial and public policy implications, as well as areas for further research.
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Background: Our aim was to identify dietary patterns by the level of maternal education that contribute to BMI, fat mass index (FMI), and fat-free mass index (FFMI) in children at age 5 and to assess if these dietary patterns are related to BMI at age 10. Methods: Per group (low/middle/high level), Reduced Rank Regression (RRR) was used to derive dietary patterns for the response variables BMI z-score, FMI, and FFMI in 1728 children at age 5 in the Amsterdam Born Children and their Development (ABCD) cohort. Regression analyses were then used to determine the association with BMI at age 10. Results: In each group, pattern 1 was characterized by its own cluster of food groups. Low: water/tea, savory snacks, sugar, low-fat meat, and fruits; middle: water/tea, low-fat cheese, fish, low-fat dairy, fruit drink, low-fat meat, and eggs; and high: low-fat cheese, fruits, whole-grain breakfast products, and low-fat and processed meat. Additionally, in each group, pattern 1 was positively associated with BMI z-scores at age 10 (low: β ≤ 0.43 [95% CI ≤ 0.21; 0.66], p < 0.001, middle: β ≤ 0.23 [0.09; 0.36], p ≤ 0.001, and high: β ≤ 0.24 [0.18; 0.30], p < 0.001). Conclusions: The dietary patterns stratified by the level of maternal education are characterized by different food groups. But in all the groups, pattern 1 is positively associated with BMI at age 10.
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Introduction by Klaas Molenaar and Margot Lobbezoo about the diversity of entrepeneurs. Every day we meet entrepreneurs; when we visit the deli at the corner, order a taxi, have a cup of tea in the bar on the other side of the street or go to a hairdresser. They are everywhere and they have many faces. And there are many opinions about entrepreneurship.
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This chapter explores the CSR actions undertaken by Eastern Produce Malawi (EPM), a subsidiary company of a multinational corporation which is based in the United Kingdom. Drawing on qualitative-based research, this chapter suggests that EPM management frames their CSR agenda through the lens of both the local and global societal challenges and expectations. This chapter shows how the contextual factors in a developing country can shape how the MNC’s global CSR standards can be translated into locally framed CSR practices. This then offers new insights into the MNC’s attempts to strike a balance between ensuring global consistency in its CSR actions and the development of CSR agenda that is responsive to local realities. The CSR agenda that EPM implements challenges the ‘one size fits all’ and the global CSR standardization thinking that sometimes dominates the CSR agenda of MNCs in different contexts.
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