From PLoS website: In general, dietary antigens are tolerated by the gut associated immune system. Impairment of this so-called oral tolerance is a serious health risk. We have previously shown that activation of the ligand-dependent transcription factor aryl hydrocarbon receptor (AhR) by the environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) affects both oral tolerance and food allergy. In this study, we determine whether a common plant-derived, dietary AhR-ligand modulates oral tolerance as well. We therefore fed mice with indole-3-carbinole (I3C), an AhR ligand that is abundant in cruciferous plants. We show that several I3C metabolites were detectable in the serum after feeding, including the high-affinity ligand 3,3´-diindolylmethane (DIM). I3C feeding robustly induced the AhR-target gene CYP4501A1 in the intestine; I3C feeding also induced the aldh1 gene, whose product catalyzes the formation of retinoic acid (RA), an inducer of regulatory T cells. We then measured parameters indicating oral tolerance and severity of peanut-induced food allergy. In contrast to the tolerance-breaking effect of TCDD, feeding mice with chow containing 2 g/kg I3C lowered the serum anti-ovalbumin IgG1 response in an experimental oral tolerance protocol. Moreover, I3C feeding attenuated symptoms of peanut allergy. In conclusion, the dietary compound I3C can positively influence a vital immune function of the gut.
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Even though mango productivity in Ethiopia is low due to moisture stress, there is no report on how such constraint could alleviate using Cocoon water-saving technology. Cocoon is small water reservoir technology which uses for plant growth in dry season. The objectives of this study were to introduce and evaluate effectiveness of water-saving techniques on mango seedlings survival and growth in Mihitsab-Azmati watershed, northern Ethiopia. In this experiment, five treatments of water-saving techniques with mango seedlings were evaluated. These were: Cocoon sprayed by tricel (T1), Cocoon painted by used engine oil (T2), Cocoon without tricel and oil (T3), manually irrigated seedlings (T4) and mango seedlings planted during rainy season (T5). The survival and growth performance of mango seedlings were recorded at six months and one-year after transplanting. Data on plant survival, height, number of leaves per plant, shoot length, stem diameter and crown width were subjected to analysis of variance and t-test. There were significant differences in the treatment effects on mango seedlings transplanted survival, plant height, number of leaves per plant, shoot length, stem diameter and crown width measured at six months and one-year after transplanting. The lowest survival rate (20 %) was found during both data collection time in T5. Six months after transplanting, the highest growth parameters were measured from T1 whereas the lowest was from T5. However, one-year after transplanting, the highest growth parameters were measured from T3. Plant heights increments between the two measurement periods for T3, T2, T1, T4 and T5 were 45.1, 38.5, 24.8, 9.8 and 7.0 cm, respectively; indicating that T3 performed better than the other treatments. The t-test on mean differences between the same growth parameter measured at 12 and six months after transplanting also showed significant differences. The Cocoon water-saving technology was superior in improving mango seedlings survival and growth in the study area. This study generalized that Cocoon seems promising, sustainable and highly scalable with mango seedlings at large-scale in the study area conditions. However, this technology should not be assumed to perform uniformly well in all environmental conditions and with all tree species before demonstrated on a pilot study.
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The Dutch greenhouse horticultural industry is characterized by world leadership in high-tech innovation. The dynamics of this playing field are innovation in production systems and automation, reduction in energy consumption and sharing limited space. However, international competitive advantage of the industry is under pressure and sustainable growth of individual enterprises is no longer a certainty. The sector's ambition is to innovate better and grow faster than the competition in the rest of the world. Realizing this ambition requires strengthening the knowledge base, stimulating entrepreneurship, innovation (not just technological, but especially business process innovation). It also requires educating and professionalizing people. However, knowledge transfer in this industry is often fragmented and innovation through collaboration takes up a mere 25-30% of the opportunities. The greenhouse horticulture sector is generally characterized by small scale, often family run businesses. Growers often depend on the Dutch auction system for their revenues and suppliers operate mainly independently. Horizontal and vertical collaboration throughout the value chain is limited. This paper focuses on the question: how can the grower and the supplier in the greenhouse horticulture chain gain competitive advantage through radical product and process innovation. The challenge lies in time- to-market, in customer relationship, in developing new product/market combinations and in innovative entrepreneurship. In this paper an innovation and entrepreneurial educational and research programme is introduced. The programme aims at strengthening multidisciplinary collaboration between enterprise, education and research. Using best practice examples, the paper illustrates how companies can realize growth and improve innovative capabilities of the organization as well as the individual by linking economic and social sustainability. The paper continues to show how participants of the programme develop competencies by means of going through a learning cycle of single-loop, double-loop and triple loop learning: reduction of mistakes, change towards new concepts and improvement of the ability to learn. Furthermore, the paper discusses our four-year programme, whose objectives are trying to eliminate interventions that stimulate the innovative capabilities of SME's in this sector and develop instruments that are beneficial to organizations and individual entrepreneurs and help them make the step from vision to action, and from incremental to radical innovation. Finally, the paper illustrates the importance of combining enterprise, education and research in networks with a regional, national and international scope, with examples from the greenhouse horticulture sector. These networks generate economic regional and national growth and international competitiveness by acting as business accelerators.
Chemical preservation is an important process that prevents foods, personal care products, woods and household products, such as paints and coatings, from undesirable change or decomposition by microbial growth. To date, many different chemical preservatives are commercially available, but they are also associated with health threats and severe negative environmental impact. The demand for novel, safe, and green chemical preservatives is growing, and this process is further accelerated by the European Green Deal. It is expected that by the year of 2050 (or even as soon as 2035), all preservatives that do not meet the ‘safe-by-design’ and ‘biodegradability’ criteria are banned from production and use. To meet these European goals, there is a large need for the development of green, circular, and bio-degradable antimicrobial compounds that can serve as alternatives for the currently available biocidals/ preservatives. Anthocyanins, derived from fruits and flowers, meet these sustainability goals. Furthermore, preliminary research at the Hanze University of Applied Science has confirmed the antimicrobial efficacy of rose and tulip anthocyanin extracts against an array of microbial species. Therefore, these molecules have the potential to serve as novel, sustainable chemical preservatives. In the current project we develop a strategy consisting of fractionation and state-of-the-art characterization methods of individual anthocyanins and subsequent in vitro screening to identify anthocyanin-molecules with potent antimicrobial efficacy for application in paints, coatings and other products. To our knowledge this is the first attempt that combines in-depth chemical characterization of individual anthocyanins in relation to their antimicrobial efficacy. Once developed, this strategy will allow us to single out anthocyanin molecules with antimicrobial properties and give us insight in structure-activity relations of individual anthocyanins. Our approach is the first step towards the development of anthocyanin molecules as novel, circular and biodegradable non-toxic plant-based preservatives.
Worldwide, coral reefs are rapidly declining due to increased sea water temperatures and other environmental stresses (Figure 1). To counter the extinction of major coral reef building species on the island of Bonaire, the non-profit organization Reef Renewal Foundation Bonaire is restoring degraded reef sites using corals that are grown in local nurseries. In these nurseries, corals are propagated on artificial trees using fragmentation. After 6-8 months of growth in the nursery, the corals are transplanted to degraded reef sites around the island. Over the years more than 21.000 corals have been outplanted to reef restoration sites in this way. These corals show high survivorship under natural reef conditions but remain under threat by environmental disturbances, such as increased water temperatures, diseases, and competition with macroalgae. A promising intervention to increase reef persistence and resilience is to manipulate the coral-associated microbiome. At present, the composition of the microbiome in nursery-reared and outplanted corals on Bonaire is unknown. The aim of the current project is to identify and isolate naturally occurring beneficial bacteria that may stimulate the resilience of these corals. Our key objectives are: 1) to assess the presence of functionally beneficial bacteria in corals in nursery and restoration sites on Bonaire using metagenomic screening. 2) to design culture strategies to isolate these functionally beneficial bacteria. In the future, a selection of these beneficial bacteria can be applied to the corals to increase their resilience against environmental disturbances.
Horticulture crops and plants use only a limited part of the solar spectrum for their growth, the photosynthetically active radiation (PAR); even within PAR, different spectral regions have different functionality for plant growth, and so different light spectra are used to influence different properties of the plant, such as leaves, fruiting, longer stems and other plant properties. Artificial lighting, typically with LEDs, has been used to provide these specified spectra per plant, defined by their light recipe. This light is called steering light. While the natural sunlight provides a much more sustainable and abundant form of energy, however, the solar spectrum is not tuned towards specific plant needs. In this project, we capitalize on recent breakthroughs in nanoscience to optimally shape the solar spectrum, and produce a spectrally selective steering light, i.e. convert the energy of the entire solar spectrum into a spectrum most useful for agriculture and plant growth to utilize the sustainable solar energy to its fullest, and save on artificial lighting and electricity. We will take advantage of the developed light recipes and create a sustainable alternative to LED steering light, using nanomaterials to optimally shape the natural sunlight spectrum, while maintaining the increased yields. As a proof of concept, we are targeting the compactness of ornamental plants and seek to steer the plants’ growth to reduce leaf extension and thus be more valuable. To realize this project the Peter Schall group at the UvA leads this effort together with the university spinout, SolarFoil, whose expertise lies in the development of spectral conversion layers for horticulture. Renolit - a plastic manufacturer and Chemtrix, expert in flow synthesis, provide expertise and technical support to scale the foil, while Ludvig-Svensson, a pioneer in greenhouse climate screens, provides the desired light specifications and tests the foil in a controlled setting.
