Little is known about the extent to which transplant recipients face emotional problems with the receipt of a transplanted organ. The Transplant Effects Questionnaire (TxEQ) enables the quantification of these problems. This study evaluates the psychometric properties of the Dutch translation of the TxEQ (TxEQ-NL) in a group of liver transplant recipients. Confirmatory factor analyses of the TxEQ-NL revealed an adequate fit with the original version. However, four items showed factor loadings <.40. Internal consistency was acceptable (.66-.79). The small correlations between the TxEQ-NL and generic measures of psychological functioning indicated that the constructs measured are related but distinguishable. Therefore, the TxEQ-NL adds a new dimension to the measurement of psychological functioning of transplant recipients.
LINK
BACKGROUND: Glucocorticoids (GCs) control expression of a large number of genes via binding to the GC receptor (GR). Transcription may be regulated either by binding of the GR dimer to DNA regulatory elements or by protein-protein interactions of GR monomers with other transcription factors. Although the type of regulation for a number of individual target genes is known, the relative contribution of both mechanisms to the regulation of the entire transcriptional program remains elusive. To study the importance of GR dimerization in the regulation of gene expression, we performed gene expression profiling of livers of prednisolone-treated wild type (WT) and mice that have lost the ability to form GR dimers (GRdim).RESULTS: The GR target genes identified in WT mice were predominantly related to glucose metabolism, the cell cycle, apoptosis and inflammation. In GRdim mice, the level of prednisolone-induced gene expression was significantly reduced compared to WT, but not completely absent. Interestingly, for a set of genes, involved in cell cycle and apoptosis processes and strongly related to Foxo3a and p53, induction by prednisolone was completely abolished in GRdim mice. In contrast, glucose metabolism-related genes were still modestly upregulated in GRdim mice upon prednisolone treatment. Finally, we identified several novel GC-inducible genes from which Fam107a, a putative histone acetyltransferase complex interacting protein, was most strongly dependent on GR dimerization.CONCLUSIONS: This study on prednisolone-induced effects in livers of WT and GRdim mice identified a number of interesting candidate genes and pathways regulated by GR dimers and sheds new light onto the complex transcriptional regulation of liver function by GCs.
DOCUMENT
The increasing amount of electronic waste (e-waste) urgently requires the use of innovative solutions within the circular economy models in this industry. Sorting of e-waste in a proper manner are essential for the recovery of valuable materials and minimizing environmental problems. The conventional e-waste sorting models are time-consuming processes, which involve laborious manual classification of complex and diverse electronic components. Moreover, the sector is lacking in skilled labor, thus making automation in sorting procedures is an urgent necessity. The project “AdapSort: Adaptive AI for Sorting E-Waste” aims to develop an adaptable AI-based system for optimal and efficient e-waste sorting. The project combines deep learning object detection algorithms with open-world vision-language models to enable adaptive AI models that incorporate operator feedback as part of a continuous learning process. The project initiates with problem analysis, including use case definition, requirement specification, and collection of labeled image data. AI models will be trained and deployed on edge devices for real-time sorting and scalability. Then, the feasibility of developing adaptive AI models that capture the state-of-the-art open-world vision-language models will be investigated. The human-in-the-loop learning is an important feature of this phase, wherein the user is enabled to provide ongoing feedback about how to refine the model further. An interface will be constructed to enable human intervention to facilitate real-time improvement of classification accuracy and sorting of different items. Finally, the project will deliver a proof of concept for the AI-based sorter, validated through selected use cases in collaboration with industrial partners. By integrating AI with human feedback, this project aims to facilitate e-waste management and serve as a foundation for larger projects.
Drones have been verified as the camera of 2024 due to the enormous exponential growth in terms of the relevant technologies and applications such as smart agriculture, transportation, inspection, logistics, surveillance and interaction. Therefore, the commercial solutions to deploy drones in different working places have become a crucial demand for companies. Warehouses are one of the most promising industrial domains to utilize drones to automate different operations such as inventory scanning, goods transportation to the delivery lines, area monitoring on demand and so on. On the other hands, deploying drones (or even mobile robots) in such challenging environment needs to enable accurate state estimation in terms of position and orientation to allow autonomous navigation. This is because GPS signals are not available in warehouses due to the obstruction by the closed-sky areas and the signal deflection by structures. Vision-based positioning systems are the most promising techniques to achieve reliable position estimation in indoor environments. This is because of using low-cost sensors (cameras), the utilization of dense environmental features and the possibilities to operate in indoor/outdoor areas. Therefore, this proposal aims to address a crucial question for industrial applications with our industrial partners to explore limitations and develop solutions towards robust state estimation of drones in challenging environments such as warehouses and greenhouses. The results of this project will be used as the baseline to develop other navigation technologies towards full autonomous deployment of drones such as mapping, localization, docking and maneuvering to safely deploy drones in GPS-denied areas.
Inleiding en praktijkvraag De groeiende wereldbevolking gecombineerd met de klimaatverandering zorgt voor een de noodzaak tot een duurzame voedselvoorziening (KIA missie Landbouw, voedsel & water). Een significante reductie van gewasbestrijdingsmiddelen is daarbinnen een belangrijke doelstelling. Robotica maakt als technologie motor van de precisielandbouw plant specifieke precisie-bestrijding mogelijk. Het projectconsortium onderzoekt een semiautonoom samenwerkend grond-luchtrobot platform voor de precisielandbouw. Projectdoelstelling De doelstelling van het project AGRobot Platform is dan ook: “Onderzoek de mogelijkheden van een semi-autonoom samenwerkend grond-lucht robotplatform voor de precisielandbouw”. De hoofddoelstelling wordt binnen dit project beantwoordt door de deliverables uit de volgende subdoelstellingen: 1. Case studie onderzoek naar de mogelijke voordelen van het grond-luchtrobotplatform 2. Onderzoek naar de benodigde technologieën voor een grond-luchtrobotplatform 3. Ontwikkelen van een eerste (mogelijk case-specifieke) demonstrator 4. Ontwikkelen van (nieuwe) samenwerkingsvormen. Vraagsturing & Netwerkvorming Riwo Engineering is een industriële automatiseeerder die met zijn grondrobots en control-besturingssytemen actief is in de veeteelt. DRONEXpert gebruikt hyperspectrale camera’s onder drones voor het bemeten van gewassen. Saxion mechatronica onderzoekt met de onderzoekslijn unmanned robotic systems hoe de nieuwste robotica technologieën systemen mogelijk maakt voor ongestructureerde omgevingen. De partners bezitten gezamenlijk een enorm netwerk (TValley, Space53, euRobotics) en klanten om via de case studies de kansen te achterhalen en te realiseren. Innovatie Nergens ter wereld is een samenwerkend grond-luchtrobot platform actief in de precisielandbouw. Voor OostNederland, met naast veel robotica kennis ook veel Agro-kennis, zal het project letterlijk de KIEM zijn voor nieuwe projecten waaruit de valorisatie kansen richting heel Europa gaan. Activiteitenplan & Projectorganisatie Het project wordt geleid door de lector Dr. Ir. D.A.Bekke en uitgevoerd door Abeje Mersha en Mark Reiling samen met het deelnemend MKB. Het project bestaat uit 4 werkpakketten die achtereenvolgens antwoordt geven op de gestelde subdoelstellingen. Aan elk werkpakket zijn deliverables gekoppeld.
