Antibiotics are a factor in developing antibiotic resistance in the environment. Outbreaks due to pathogens and resistant bacteria are an emerging issue in this decade. Resistance of Escherichia coli to two groups of antibiotics has been revised recently by the World Health Organization (WHO). These data showed that bacteria have already developed resistance to third and fourth group of antibiotics. The WHO report on surveillance and antibiotics consumption evaluation showed that antibiotic consumption varies in EU countries. Outbreaks have increased in parallel to these data depending on country, season, sex, and age group. This chapter revises the routes of spreading and surveillance of E. coli. There is a particular focus on water sources including hospitals, urban wastewater treatment plants (UWTPs), diffuse sources, and water reuse. Extensively revised data are given on the control techniques by biological and advanced processes. The emerging issue of gene transfer control in parallel to the control of bacteria is expressed. A detailed literature survey of emerging technologies of photocatalysis and nanoparticles is given.
