Background: Since 2000, the prevalence of recreational nitrous oxide (N 2O) use has increased in the Western world. Although N 2O is a relatively safe drug, the overall increase in the use of N 2O has concomitantly also initiated a modest but important increase in the number of young excessive users. The recent introduction of large 2 kg N 2O tanks, allowing high and prolonged dosing, has facilitated this excessive use. This is of concern, because repeated exposure to high doses of N 2O for a prolonged time is known to induce neurological damage, such as (irreversible) neuropathy and paralysis due to N 2O-induced vitamin B 12 deficiency. The increasing trend of recreational users with N 2O-induced neurological damage at emergency departments confirms the urgency of this development. Objective/Methods: This narrative review describes recent trends in N 2O use and misuse, the adverse health effects associated with excessive use and the risk factors of excessive use. Results: Considering the rising trend in N 2O use, particularly among young and other vulnerable people, we propose to take legislative action to limit the availability of N 2O, and also advocate for better and timely education of non-users, users and medical professionals about the serious side-effects associated with excessive N 2O use. Conclusion: It is concluded that the increase in excessive N 2O use is of serious concern.
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Keynote presentatie tijdens het HRM Praktijk Onderzoek Congres 14 november. Over het thema: 'De veranderende waarde(n) van werk: gevolgen voor HRMTrends in werk. Werk is veranderd en verandert nog steeds. Banen waar we 10 jaar geleden nog nooit van gehoord hadden, worden nu veelvuldig gevraagd, maar kunnen ook weer verdwijnen. De situatie op de werkvloer is niet meer te vergelijken met die van enkele decennia geleden. Er is veel meer variatie: meer vrouwen, allochtonen en parttimers, om maar eens wat te noemen. Organisaties werken tijdelijk samen aan projecten en hun medewerkers dus ook. Functies veranderen voortdurend. Hoe spelen organisatie in het algemeen en HRM in het bijzonder hier op in? Hoe bereid je medewerkers adequaat voor op voortdurende verandering? Welke consequenties hebben al die veranderingen voor het HRM beleid in organisaties?
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Self-efficacy and outcome expectations regarding client activation determine professionals’ level of actively engaging clients during daily activities. The Client Activation Self-Efficacy and Outcome Expectation Scales for nurses and domestic support workers (DSWs) were developed to measure these concepts. This study aimed to assess their psychometric properties. Cross-sectional data from a sample of Dutch nurses (n=150) and DSWs (n=155) were analysed. Descriptive statistics were used to examine floor and ceiling effects. Construct validity was assessed by testing research-based hypotheses. Internal consistency was determined with Cronbach’s alpha. The scales for nurses showed a ceiling effect. There were no floor or ceiling effects in the scales for domestic support workers. Three out of five hypotheses could be confirmed (construct validity). For all scales, Cronbach’s alpha coefficients exceeded 0.70. In conclusion, all scales had moderate construct validity and high internal consistency. Further research is needed concerning their construct validity, testretest reliability and sensitivity to change.
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Recently, we have introduced and modified graph-decomposition theorems based on a graph product motivated by applications in the context of synchronising periodic real-time processes. This vertex-removing synchronised product (VRSP) is based on modifications of the well-known Cartesian product and is closely related to the synchronised product due to Wöhrle and Thomas. Here, we introduce a new graph-decomposition theorem based on the VRSP that decomposes an edge-labelled acyclic n-partite multigraph where all labels are the same.
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We generalize the method of computing functional determinants with a single excluded zero eigenvalue developed by McKane and Tarlie to differential operators with multiple zero eigenvalues. We derive general formulas for such functional determinants of $r\times r$ matrix second order differential operators O with $0 < n \leqslant 2r$ linearly independent zero modes. We separately discuss the cases of the homogeneous Dirichlet boundary conditions, when the number of zero modes cannot exceed r, and the case of twisted boundary conditions, including the periodic and anti-periodic ones, when the number of zero modes is bounded above by 2r. In all cases the determinants with excluded zero eigenvalues can be expressed only in terms of the n zero modes and other $r-n$ or $2r-n$ (depending on the boundary conditions) solutions of the homogeneous equation $O h=0$ , in the spirit of Gel'fand–Yaglom approach. In instanton calculations, the contribution of the zero modes is taken into account by introducing the so-called collective coordinates. We show that there is a remarkable cancellation of a factor (involving scalar products of zero modes) between the Jacobian of the transformation to the collective coordinates and the functional fluctuation determinant with excluded zero eigenvalues. This cancellation drastically simplifies instanton calculations when one uses our formulas.
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In this study we use aggregated weighted scores of environmental effects to study environmental influences on well-being and happiness. To this end, we split a sample of Netherlands Twin Register (NTR) participants into a training (N =4857) and test (N =2077) sample. In the training sample, we use elastic net regression to estimate effect sizes for associations between life satisfaction and two sets of environmental variables: one based on self- report socioenvironmental data, and one based on objective physical environmental data. Based on these effect sizes, we create two poly-environmental scores (PES-S and PES-O, for self-reports and objective data respectively). In the test sample, we perform association analyses between different measures of well-being and the two PESs. We find that the PES-S explains ~36% of the variance in well-being, while the PES-O does not significantly contribute to the model. Variance in other well-being measures (i.e., different life satisfaction domains, subjective happiness, quality of life, flourishing, psychological well-being, self-rated health, depressive problems, and loneliness) are explained to varying extents by the PESs, ranging from 6.36% (self-rated health) to 36.66% (loneliness). These predictive values did not change during the COVID-19 pandemic (N =3214). Validating the PES-S in the UK biobank (N =40,614), we find that the UK biobank PES-S explains about ~12% of the variance in happiness. Lastly, we examine if there is any indication for gene-environment correlation (rGE), the phenomenon where one’s genetic predisposition influences exposure to the environment, by associating the PESs with polygenic scores (PGS) in a sample of Netherlands Twin Register (NTR) and UK Biobank participants. While the PES and PGS were not correlated in the NTR sample, they were correlated in the larger UK biobank sample, indicating the potential presence of rGE. We discuss several limitations pertaining to our dataset, such as a potential influence of common method bias, and reflect on how PESs might be used in future research.
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Een grote groep Nederlanders wordt jaarlijks slachtoffer van phishing. Burgers en bedrijven nemen echter in te beperkte mate zelfbeschermende maatregelen. In dit onderzoek wordt in kaart gebracht welke factoren bijdragen aan de intentie om zelfbeschermende maatregelen te nemen tegen phishing door drie risicogroepen, namelijk jongeren, ouderen en mkb’ers. We passen de Protection Motivation Theory toe, en onderbouwen een uitbreiding van dit model met twee factoren: affectieve respons en subjectieve normen. Data is verzameld middels vragenlijstonderzoek bij een panelbureau onder jongeren (N=1179), ouderen (N=1191) en mkb’ers (N=1020). De sterkste voorspeller voor de intentie tot het nemen van zelfbeschermende maatregelen tegen phishing bleek de affectieve respons (zorgen maken om phishing), gevolgd door een negatief effect van zelfeffectiviteit en positieve effecten van waargenomen ernst (jongeren en mkb’ers) en subjectieve norm (mkb’ers). Implicaties van de bevindingen voor handhavers en interventies worden besproken.
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