The Procurement and Supply of hospital isolation gowns (IGs) pose significant challenges, including the potential for sudden increases in demand, the necessity of maintaining high-quality gowns, and the complexity of the supply process. One potential solution to these challenges is the investment in reusable IGs, which may seem financially infeasible due to their initial purchasing price. However, it can provide long-term financial and environmental benefits. In this research, a Simulation Optimization (SO) framework is utilized to model and analyze various product portfolio selection strategies, considering both financial and environmental perspectives, and to determine the optimal strategy for meeting both financial and environmental objectives. The proposed strategy is implemented to the problem based on obtained Life Cycle Assessment and market data.