To compare comfort‐related outcomes when wearing rigid gas permeable (RGP) contact lenses made of two different materials and using two cleaning regimes. In a double‐masked lens material cross‐over study, subjects (n = 28 who completed the study) were refitted with new lenses made from (A) Boston XO material in one eye and made from (B) ONSI‐56 material in the other eye. The lenses made from materials A and B were worn on the right eye and the left eye following the pattern AB–BA–AB (or vice versa) during the first, second, and third 5 week trial periods respectively. Miraflow cleaner (1st and 2nd period) was replaced by Boston Advance cleaner in the 3rd period. Comfort‐related outcomes were assessed by a numerical rating scale (NRS) after each period. Subjects rated six comfort‐related factors: satisfaction, sharpness of vision, end of day comfort, maximum comfortable wearing time, maximum wearing time and foreign body feeling. Additionally we obtained subjects’ preferences for type of lens and lens cleaner during an exit interview. The sessile drop method was used to measure static contact angles.