Background/Objectives: Personalized and self-initiated dietary adjustments have been shown to alleviate mental and somatic complaints. Here, we investigated the potential role of gut microbiome alterations underlying these effects. Methods: For this purpose, participants (n = 185) underwent a four-week self-initiated dietary intervention and filled out weekly questionnaires on their dietary intake, somatic and mental symptoms, and physical activity. Results: Overall, the participants lost weight, had alleviated mental and somatic complaints, reduced their total caloric and percentual carbohydrate intake, and ate less processed, party-type, and traditional Dutch food items, but ate more Pescatarian type food items, while keeping their fiber intake unaltered. Baseline and endpoint gut microbiota analyses using 16S rRNA gene sequencing revealed an overall increase in Gemmiger formicilis and reductions in Peptostreptococcaceae and Ruminococcus bromii over the four-week dietary intervention. While these bacterial alterations were considered to be beneficial for the host, they were not individually correlated with alterations in, or endpoint levels of, somatic and/or mental complaints. Instead, individual increases in Ruminococcus bicirculans (a well-known utilizer of plant cell wall polysaccharides) were strongly correlated with reductions in mental complaints, even though overall R. bicirculans remained unaltered over the course of the four-week self-initiated dierary intervention. Conclusions: Our results suggest that overall altered versus individually correlated microbiota abundances and their relations with host health characteristics over the course of a self-chosen dietary intervention may represent different levels of regulation, which remain to be further untangled.
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The workshop aims to understand how a living lab network structures contribute to system innovation. Living labs as system innovation initiatives can substantially alter established network structures. Moreover, structures can undergo alterations through subtle interventions, with impact on the overall outcomes of living labs. To understand how such change occurs, we develop a multilevel network perspective to study collaborations toward system innovation. We take this perspective to help understand living lab dynamics, drawing on innovative examples and taking into consideration the multilayered structures that the collaboration comprises.
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Abstract: Plan adaptation during the course of (chemo)radiotherapy of H&N cancer requires repeat CT scanning to capture anatomy changes such as parotid gland shrinkage. Hydration, applied to prevent nephrotoxicity from cisplatin, could temporarily alter the hydrogen balance and hence the captured anatomy. The aim of this study was to determine geometric changes of parotid glands as function of hydration during chemoradiotherapy compared to a control group treated with radiotherapy only.
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from the article: ABSTRACT Independence of design, information and complexity are the basic concepts of Axiomatic Design. These basic concepts have proven to be generic; axiomatic design was successfully applied in many markets and on a broad range of products and services. Information, or entropy, plays a central role in Axiomatic Design. In this paper an attempt is made to organise the different kinds of information, understand them, and evaluate the consequences of the ways they can be applied. A number of six kinds of information are reduced to two most determining kinds of information for the design. Unorganised information is about choosing the right and independent design relations. Axiomatic information is about further optimisation of these design relations. This paper leads to the confirmation that axiom 1 & 2 are in fact corollaries of the complexity axiom that is constituted of the two kinds of information. Though this revises the foundation of Axiomatic Design, the operation and practical application are not much affected for a number of reasons. One of them is that a higher axiom does not alter the basic ideas behind Axiomatic Design; it remains axiomatic.
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As many in society work towards global sustainability, we live at a time when efforts to conserve biodiversity and geodiversity, and combat climate change, take place simultaneously with land grabs by large corporations, food insecurity, and human displacement through an ecological breakdown. Many of us seek to reconcile more-than-human nature and human nature and to balance intrinsic value and the current human expansion phase. These and other challenges will fundamentally alter the way people, depending on their worldview and ethics, relate to communities and the environment. While environmental problems cannot be seen as purely ecological because they always involve people, who bring to the environmental table their different assumptions about nature and culture, so are social problems connected to environmental constraints. Similarly, social problems are fundamentally connected to environmental constraints and ecological health. While nonhumans cannot bring anything to this negotiating table, the distinct perspective of this book is that there is a need to consider the role of nonhumans as equally important stakeholders – albeit without a voice. This book develops an argument that human-environmental relationships are set within ecological reality and ecological ethics. Rather than being mutually constitutive processes, humans have obligate dependence on nature, not vice versa. We argue that over-arching ecological ethics is necessary to underpin conservation in the long-term. This requires a holistic ‘justice’, where both social justice (for humans) and ecological justice (for nature) are entwined. However, given the escalating environmental crisis and major extinction event we face, and given that social justice has been dominant for centuries, we believe that in many cases ecojustice will need to be prioritized. This will depend on the situation, but we feel that under ecological ethics, holistic ethics cannot always allow social justice to dominate, hence there is an urgent need to prioritize ecojustice today. Accordingly, this book will deal with questions of both social and ecological justice, putting forth the idea that justice for both humans and nonhumans and their habitats can only be achieved simultaneously. This book will explore the following questions: What is the relationship between social and ecological justice? How might we integrate social and ecological justice? What are the major barriers to achieving this simultaneous justice? How can these barriers be overcome? What are the major debates in conservation relevant to this? doi: 10.1007/978-3-030-13905-6 LinkedIn: https://www.linkedin.com/in/helenkopnina/
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Treatment guidelines difer signifcantly, not only between Europe and North America but also among European countries [1–4]. Reasons for these diferences include antimicrobial resistance patterns, accessibility to and reimbursement policies for medicines, and culturally and historically determined prescribing attitudes. The European Association of Clinical Pharmacology and Therapeutics’ Education Working Group has launched several initiatives to improve and harmonize European pharmacotherapy education, but international diferences have proven to be a major barrier to these eforts [5–7]. While we have taken steps to chart these diferences [6, 8], it will probably not be possible to fully resolve them. Rather than viewing these diferences as a barrier, we should perhaps see them as an opportunity for intercultural learning by providing students and teachers a valuable lesson in the context-dependent nature of prescribing medication and the diferent interpretations of evidence-based medicine. Here, we extend our experience with interprofessional student-run clinics [9, 10], to report on our first experiences with the “International and Interprofessional Student-run Clinic.” We organized three successful video meetings with medical and pharmacy students of the Amsterdam UMC, location VU University (the Netherlands), and the University of Bologna (Italy). During these meetings, one of the students presented a real-life case of a patient on polypharmacy. Then, in a 45-min session, the students split into smaller groups (break-out rooms) to review the patient’s medication, using the prescribing optimization method and STOPP/ START criteria [11, 12]. The teachers rotated between the diferent rooms and assisted the students when necessary. Teachers and students reconvened for 60 min for debriefng, with students presenting their fndings and suggestions to revise the medication list and teachers stimulating discussion and indicating how they would alter the medication list. Participation was voluntary, and the meetings were held in the evenings to accommodate students in clinical rotations. Third-to-fnal-year medical and pharmacy students participated in the three meetings (n=17, n=20, n=12, respectively). They reported learning a lot from each other, gaining an international and interprofessional perspective. Moreover, they learned to always consider the patient’s perspective, that evidence-based medicine is context-dependent, and that guidelines should be adapted to the patient’s situation.
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Happiness and (mis)fortune are very individual matters of different origins: mental and material. They can not be (directly) traced back to each other. Prosperity can always turn into adversity and vice versa. This does not alter the fact that someone who has made courage or cheerfulness her second nature, has a different attitude to life than someone who, for example, has made lability into second nature. So if we can not opt for fame and fortune, we can choose to develop our second nature, and it is precisely those choices (plural) that make us who we are!
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Urban densification is a key strategy to accommodate rapid urban population growth, but emerging evidence suggests serious risks of urban densification for individuals’ mental health. To better understand the complex pathways from urban densification to mental health, we integrated interdisciplinary expert knowledge in a causal loop diagram via group model building techniques. Six subsystems were identified: five subsystems describing mechanisms on how changes in the urban system caused by urban densification may impact mental health, and one showing how changes in mental health may alter urban densification. The new insights can help to develop resilient, healthier cities for all.
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