Gebruikt bij post-bachelorcursus Using R for Data Analysis: "... verdiep je je in de programmeertaal R. Dit is een programmeertaal die reproduceerbaarheid van onderzoek en data-analyse verhoogt. R wordt tegenwoordig breed gebruikt binnen verschillende takken van de wetenschap en daarnaast door grote data gedreven bedrijven als Facebook en Google". Zie https://www.hu.nl/deeltijd-opleidingen/using-r-for-data-analysis
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Presentation at the Annual Lego(r) Serious Play(r) conference of the Certified Lego Serious Play facilitators in Denmark
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Various diazo compounds, nitrile oxides, nitrones and azomethine ylides were examined in 1,3-dipolar cycloadditions to enantiomerically pure 5-(R)-menthyloxy-2(5H)-furanone 1a. Pyrazoline 9 was obtained in 100% c.y. as a mixture of 2 diastereoisomers in ratios up to 72: 28, whereas pyrazoline 16 was obtained in 100 % c.y. as a single enantiomer. Photochemically pyrazolines 9 and 10 have been converted to cyclopropanes 11 and 13. Under thermal conditions pyrazoline 9 is converted to 4-methyl-5-menthyloxy-2(5H)-furanone. Isoxazoles 21a-24a were obtained enantiomerically pure via nitrile oxide addition to 1a in 64-67% yield. Nitrone addition afforded isoxazolidines 27, 28 and 34 with complete anti-facial- and regiochemistry, but with endo-exo selectivities up to 76%. Enantiomerically pure isoxazolidines were obtained in 25-75% yield. Pyrrolidine 36 was obtained diastereomerically pure in 81% c.y. Pyrrolidines 42 and 45, however, were obtained as diastereomeric mixtures in 37% resp. 6% yield. © 1994.
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Drawing on a multiple case study of acquisitions of UK biopharmaceutical firms, we develop an analytical framework that elucidates how key determinants of the knowledge base of science-based firms and their combinations through M&As interact and affect post-acquisition investment in the target's R&D projects. We show that two factors - the complementarity/similarity of the technology, and the complementarity/similarity of the discovery and development capabilities of the target and acquiring firm - interact to produce different outcomes in terms of investment in the acquired firm's R&D assets and for the local science and technology system.
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De geruchtmakende uitzending van Peter R. de Vries op 3 februari 2008 over de raadselachtige verdwijning van Natalee Holloway heeft naast psychologische en strafrechtelijke ook media-ethische vragen opgeroepen. Zo is er de vraag wanneer je in een informatief programma gebruik mag maken van de verborgen camera. En mag je iemand interviewen wanneer je merkt dat hij stoned is? Moet zo iemand niet tegen zichzelf in bescherming worden genomen? Wat te doen wanneer je als redactie tot de conclusie komt, dat iemand een pathologische leugenaar is? Moet je dat dan niet minstens expliciet in de uitzending melden? Zonder twijfel was er sprake van wat wel 'trial by media' genoemd wordt: los van de strafrechtelijke schuld en veroordeling is er de veroordeling door de media bij wijze van volksgericht. Voor het grote publiek is Joran van der Sloot de schuldige. De schandpaal staat niet meer op het marktplein, maar in onze huiskamers.
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BACKGROUND: The quality standards of the Dutch Society of Intensive Care require monitoring of the satisfaction of patient's relatives with respect to care. Currently, no suitable instrument is available in the Netherlands to measure this. This study describes the development and psychometric evaluation of the questionnaire-based Consumer Quality Index 'Relatives in Intensive Care Unit' (CQI 'R-ICU'). The CQI 'R-ICU' measures the perceived quality of care from the perspective of patients' relatives, and identifies aspects of care that need improvement.METHODS: The CQI 'R-ICU' was developed using a mixed method design. Items were based on quality of care aspects from earlier studies and from focus group interviews with patients' relatives. The time period for the data collection of the psychometric evaluation was from October 2011 until July 2012. Relatives of adult intensive care patients in one university hospital and five general hospitals in the Netherlands were approached to participate. Psychometric evaluation included item analysis, inter-item analysis, and factor analysis.RESULTS: Twelve aspects were noted as being indicators of quality of care, and were subsequently selected for the questionnaire's vocabulary. The response rate of patients' relatives was 81% (n = 455). Quality of care was represented by two clusters, each showing a high reliability: 'Communication' (α = .80) and 'Participation' (α = .84). Relatives ranked the following aspects for quality of care as most important: no conflicting information, information from doctors and nurses is comprehensive, and health professionals take patients' relatives seriously. The least important care aspects were: need for contact with peers, nuisance, and contact with a spiritual counsellor. Aspects that needed the most urgent improvement (highest quality improvement scores) were: information about how relatives can contribute to the care of the patient, information about the use of meal-facilities in the hospital, and involvement in decision-making on the medical treatment of the patient.CONCLUSIONS: The CQI 'R-ICU' evaluates quality of care from the perspective of relatives of intensive care patients and provides practical information for quality assurance and improvement programs. The development and psychometric evaluation of the CQI 'R-ICU' led to a draft questionnaire, sufficient to justify further research into the reliability, validity, and the discriminative power of the questionnaire.
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The ultimate goal of FAIR is to optimize the Reuse of data. To achieve this, metadata and data should be well-described and documented so that they can be replicated, understood and/or combined in different settings. Think of variable labels, codebooks, protocols and instruments used, attaching a license, etc. This checklist details what to include in a data package besides the data itself. The data package can be deposited in data repository such as UvA/HvA figshare.
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A panel discussing the current outcomes of R&D related to the state of video game development, content, and policy in Europe, with a particular interest in how this compares with treatment of 'traditional' cultural mediums.
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